gem-Diethyl Pyrroline Nitroxide Spin Labels: Synthesis, EPR Characterization, Rotamer Libraries and Biocompatibility

Stephanie Bleicken, Tufa E. Assafa, Hui Zhang, Christina Elsner, Irina Ritsch, Maren Pink, Suchada Rajca, Gunnar Jeschke, Andrzej Rajca, Enrica Bordignon

Research output: Contribution to journalComment/debate

6 Scopus citations


Invited for this month's cover picture is the group of Professor Enrica Bordignon at the Ruhr University Bochum. The cover picture shows an artistic view of E. coli cells and two spin-labeled recombinantly produced proteins, which can be inserted into the cells for EPR studies. The primary sequence of the proteins is schematically shown with the one-letter amino acid code, and cysteine residues are functionalized with the two new gem diethyl nitroxide spin labels designed to better sustain the reducing cellular environment. Read the full text of their Full Paper at 10.1002/open.201900119.

Original languageEnglish (US)
Number of pages1
Issue number8
StatePublished - Jan 1 2019


ASJC Scopus subject areas

  • Chemistry(all)

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