Gene duplication and evolutionary innovations in hemoglobin-oxygen transport

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


During vertebrate evolution, duplicated hemoglobin (Hb) genes diverged with respect to functional properties as well as the developmental timing of expression. For example, the subfamilies of genes that encode the different subunit chains of Hb are ontogenetically regulated such that functionally distinct Hb isoforms are expressed during different developmental stages. In some vertebrate taxa, functional differentiation between co-expressed Hb isoforms may also contribute to physiologically important divisions of labor.

Original languageEnglish (US)
Pages (from-to)223-232
Number of pages10
Issue number3
StatePublished - May 2016

ASJC Scopus subject areas

  • Physiology


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