TY - JOUR
T1 - Gene duplication and the evolution of hemoglobin isoform differentiation in birds
AU - Grispo, Michael T.
AU - Natarajan, Chandrasekhar
AU - Projecto-Garcia, Joana
AU - Moriyama, Hideaki
AU - Weber, Roy E.
AU - Storz, Jay F.
PY - 2012/11/2
Y1 - 2012/11/2
N2 - Background: The functional significance of hemoglobin heterogeneity remains a mystery. Results: In adult birds, the HbD isoform (related to embryonic hemoglobin) exhibits distinct oxygenation properties relative to the major HbA isoform. Conclusion: Substitutions that distinguish HbD from HbA are not shared with embryonic hemoglobin. Significance: Differences between isoforms stem from derived (nonancestral) changes in duplicated genes, not from the retention of an ancestral condition.
AB - Background: The functional significance of hemoglobin heterogeneity remains a mystery. Results: In adult birds, the HbD isoform (related to embryonic hemoglobin) exhibits distinct oxygenation properties relative to the major HbA isoform. Conclusion: Substitutions that distinguish HbD from HbA are not shared with embryonic hemoglobin. Significance: Differences between isoforms stem from derived (nonancestral) changes in duplicated genes, not from the retention of an ancestral condition.
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U2 - 10.1074/jbc.M112.375600
DO - 10.1074/jbc.M112.375600
M3 - Article
C2 - 22962007
AN - SCOPUS:84868322931
SN - 0021-9258
VL - 287
SP - 37647
EP - 37658
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 45
ER -