Gene duplication and the evolution of hemoglobin isoform differentiation in birds

Michael T. Grispo, Chandrasekhar Natarajan, Joana Projecto-Garcia, Hideaki Moriyama, Roy E. Weber, Jay F. Storz

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Background: The functional significance of hemoglobin heterogeneity remains a mystery. Results: In adult birds, the HbD isoform (related to embryonic hemoglobin) exhibits distinct oxygenation properties relative to the major HbA isoform. Conclusion: Substitutions that distinguish HbD from HbA are not shared with embryonic hemoglobin. Significance: Differences between isoforms stem from derived (nonancestral) changes in duplicated genes, not from the retention of an ancestral condition.

Original languageEnglish (US)
Pages (from-to)37647-37658
Number of pages12
JournalJournal of Biological Chemistry
Volume287
Issue number45
DOIs
StatePublished - Nov 2 2012

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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