Gene expression phenotypes of atherosclerosis

David Seo, Tao Wang, Holly Dressman, Edward E. Herderick, Edwin S. Iversen, Chunming Dong, Korkut Vata, Carmelo A. Milano, Fabio Rigat, Jennifer Pittman, Joseph R. Nevins, Mike West, Pascal J. Goldschmidt-Clermont

Research output: Contribution to journalArticle

111 Scopus citations

Abstract

Objective - Fulfilling the promise of personalized medicine by developing individualized diagnostic and therapeutic strategies for atherosclerosis will depend on a detailed understanding of the genes and gene variants that contribute to disease susceptibility and progression. To that end, our group has developed a nonbiased approach congruent with the multigenic concept of complex diseases by identifying gene expression patterns highly associated with disease states in human target tissues. Methods and Results - We have analyzed a collection of human aorta samples with varying degrees of atherosclerosis to identify gene expression patterns that predict a disease state or potential susceptibility. We find gene expression signatures that relate to each of these disease measures and are reliable and robust in predicting the classification for new samples with >93% in each analysis. The genes that provide the predictive power include many previously suspected to play a role in atherosclerosis and additional genes without prior association with atherosclerosis. Conclusion - Hence, we are reporting a novel method for generating a molecular phenotype of disease and then identifying genes whose discriminatory capability strongly implicates their potential roles in human atherosclerosis.

Original languageEnglish (US)
Pages (from-to)1922-1927
Number of pages6
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume24
Issue number10
DOIs
StatePublished - Oct 1 2004

Keywords

  • Clinical human atherosclerosis
  • Disease genetic susceptibility
  • Gene expression profile
  • Genomic
  • Molecular signature

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Seo, D., Wang, T., Dressman, H., Herderick, E. E., Iversen, E. S., Dong, C., Vata, K., Milano, C. A., Rigat, F., Pittman, J., Nevins, J. R., West, M., & Goldschmidt-Clermont, P. J. (2004). Gene expression phenotypes of atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 24(10), 1922-1927. https://doi.org/10.1161/01.ATV.0000141358.65242.1f