TY - JOUR
T1 - Gene expression profiling with DNA microarrays
T2 - Advancing our understanding of psychiatric disorders
AU - Pongrac, Julie
AU - Middleton, Frank A.
AU - Lewis, David A.
AU - Levitt, Pat
AU - Mirnics, Karoly
PY - 2002/10/1
Y1 - 2002/10/1
N2 - DNA microarray transcriptome profiling of the postmortem brain opens novel horizons in understanding molecular changes associated with complex psychiatric disorders. With careful analysis and interpretation of microarray data we are uncovering previously unknown, expression patterns that maybe subject-specific and pivotal in understanding the disease process. In our recent studies, analyses of the prefrontal cortex of subjects with schizophrenia and matched controls uncovered complex changes in the expression of genes related to presynaptic secretory release, GABAergic and glutamatergic transmission, metabolic pathways, myelination, as well as cAMP and phosphoinositol second messenger systems. Our goal will be to integrate this expression data within the context of the relevant anatomical, biochemical, molecular, imaging and clinical findings.
AB - DNA microarray transcriptome profiling of the postmortem brain opens novel horizons in understanding molecular changes associated with complex psychiatric disorders. With careful analysis and interpretation of microarray data we are uncovering previously unknown, expression patterns that maybe subject-specific and pivotal in understanding the disease process. In our recent studies, analyses of the prefrontal cortex of subjects with schizophrenia and matched controls uncovered complex changes in the expression of genes related to presynaptic secretory release, GABAergic and glutamatergic transmission, metabolic pathways, myelination, as well as cAMP and phosphoinositol second messenger systems. Our goal will be to integrate this expression data within the context of the relevant anatomical, biochemical, molecular, imaging and clinical findings.
KW - Expression
KW - Gene
KW - Human
KW - Microarray
KW - Profiling
KW - Psychiatric
UR - http://www.scopus.com/inward/record.url?scp=0036807851&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036807851&partnerID=8YFLogxK
U2 - 10.1023/A:1020904821237
DO - 10.1023/A:1020904821237
M3 - Article
C2 - 12462404
AN - SCOPUS:0036807851
SN - 0364-3190
VL - 27
SP - 1049
EP - 1063
JO - Neurochemical Research
JF - Neurochemical Research
IS - 10
ER -