TY - JOUR
T1 - Gene flow mediates the role of sex chromosome meiotic drive during complex speciation
AU - Meiklejohn, Colin D.
AU - Landeen, Emily L.
AU - Gordon, Kathleen E.
AU - Rzatkiewicz, Thomas
AU - Kingan, Sarah B.
AU - Geneva, Anthony J.
AU - Vedanayagam, Jeffrey P.
AU - Muirhead, Christina A.
AU - Garrigan, Daniel
AU - Stern, David L.
AU - Presgraves, Daven C.
N1 - Publisher Copyright:
© Meiklejohn et al.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - During speciation, sex chromosomes often accumulate interspecific genetic incompatibilities faster than the rest of the genome. The drive theory posits that sex chromosomes are susceptible to recurrent bouts of meiotic drive and suppression, causing the evolutionary buildup of divergent cryptic sex-linked drive systems and, incidentally, genetic incompatibilities. To assess the role of drive during speciation, we combine high-resolution genetic mapping of X-linked hybrid male sterility with population genomics analyses of divergence and recent gene flow between the fruitfly species, Drosophila mauritiana and D. simulans. Our findings reveal a high density of genetic incompatibilities and a corresponding dearth of gene flow on the X chromosome. Surprisingly, we find that a known drive element recently migrated between species and, rather than contributing to interspecific divergence, caused a strong reduction in local sequence divergence, undermining the evolution of hybrid sterility. Gene flow can therefore mediate the effects of selfish genetic elements during speciation.
AB - During speciation, sex chromosomes often accumulate interspecific genetic incompatibilities faster than the rest of the genome. The drive theory posits that sex chromosomes are susceptible to recurrent bouts of meiotic drive and suppression, causing the evolutionary buildup of divergent cryptic sex-linked drive systems and, incidentally, genetic incompatibilities. To assess the role of drive during speciation, we combine high-resolution genetic mapping of X-linked hybrid male sterility with population genomics analyses of divergence and recent gene flow between the fruitfly species, Drosophila mauritiana and D. simulans. Our findings reveal a high density of genetic incompatibilities and a corresponding dearth of gene flow on the X chromosome. Surprisingly, we find that a known drive element recently migrated between species and, rather than contributing to interspecific divergence, caused a strong reduction in local sequence divergence, undermining the evolution of hybrid sterility. Gene flow can therefore mediate the effects of selfish genetic elements during speciation.
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U2 - 10.7554/eLife.35468
DO - 10.7554/eLife.35468
M3 - Article
C2 - 30543325
AN - SCOPUS:85058612470
SN - 2050-084X
VL - 7
JO - eLife
JF - eLife
M1 - e35468
ER -