Gene therapy for rheumatoid arthritis

Adam Reinhardt, Raphael Hirsch

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Therapy for rheumatoid arthritis (RA) has seen significant advances over the Past decade. The use of biologic agents, such as TNF-α inhibitors, have led to improvement in up to 60% of RA patients. Unfortunately, biologic therapy also presents significant limitations, including systematic side effects, a short half-life with requirement for frequent dosing, and a lack of curative response. Owing to such limitations, the ideal therapy for RA remains unrealized. Progress in the field of gone therapy provides interesting and applicable methods to overcome many of these deficits. In this review we will discuss some of these advances, focusing on the development of new vectors, gene-therapy targets and regulatory mechanisms. With continued efforts in this field, the hope for a lasting, regulated and possibly curative modality appears attainable.

Original languageEnglish (US)
Pages (from-to)403-413
Number of pages11
JournalFuture Rheumatology
Volume2
Issue number4
DOIs
StatePublished - Aug 2007

Keywords

  • Adeno-associated virus
  • Adenovirus
  • Gene therapy
  • Inflammation
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology

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