Generalized additive regression for group testing data

Yan Liu, Christopher S. McMahan, Joshua M. Tebbs, Colin M. Gallagher, Christopher R. Bilder

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

In screening applications involving low-prevalence diseases, pooling specimens (e.g., urine, blood, swabs, etc.) through group testing can be far more cost effective than testing specimens individually. Estimation is a common goal in such applications and typically involves modeling the probability of disease as a function of available covariates. In recent years, several authors have developed regression methods to accommodate the complex structure of group testing data but often under the assumption that covariate effects are linear. Although linearity is a reasonable assumption in some applications, it can lead to model misspecification and biased inference in others. To offer a more flexible framework, we propose a Bayesian generalized additive regression approach to model the individual-level probability of disease with potentially misclassified group testing data. Our approach can be used to analyze data arising from any group testing protocol with the goal of estimating multiple unknown smooth functions of covariates, standard linear effects for other covariates, and assay classification accuracy probabilities. We illustrate the methods in this article using group testing data on chlamydia infection in Iowa.

Original languageEnglish (US)
Pages (from-to)873-889
Number of pages17
JournalBiostatistics
Volume22
Issue number4
DOIs
StatePublished - Oct 13 2021

Keywords

  • Bayesian regression
  • Binary regression
  • Gaussian predictive process
  • Gaussian process
  • Pooled testing
  • Specimen pooling

ASJC Scopus subject areas

  • Statistics and Probability
  • Statistics, Probability and Uncertainty

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