Generation and characterization of monoclonal antibodies against the proregion of human desmoglein-2

Sarah A. Keim; Keith R. Johnson; Margaret J. Wheelock; James K. Wahl

doi:10.1089/hyb.2008.0020

Generation and characterization of monoclonal antibodies against the proregion of human desmoglein-2

Sarah A. Keim, Keith R. Johnson, Margaret J. Wheelock, James K. Wahl

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10 Scopus citations

Abstract

Cadherins are synthesized with a signal sequence and a proregion that must be removed for optimal adhesive activity. Mutations that prevent processing of cadherins have been implicated in a number of human diseases; thus understanding their processing is critical. In this study, we produced and characterized a number of monoclonal antibodies against the proregion of the desmosomal cadherin, human desmoglein-2, that will facilitate investigations into the processing of this protein.

Original language	English (US)
Pages (from-to)	249-258
Number of pages	10
Journal	Hybridoma
Volume	27
Issue number	4
DOIs	https://doi.org/10.1089/hyb.2008.0020
State	Published - Aug 1 2008

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1089/hyb.2008.0020

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abstract = "Cadherins are synthesized with a signal sequence and a proregion that must be removed for optimal adhesive activity. Mutations that prevent processing of cadherins have been implicated in a number of human diseases; thus understanding their processing is critical. In this study, we produced and characterized a number of monoclonal antibodies against the proregion of the desmosomal cadherin, human desmoglein-2, that will facilitate investigations into the processing of this protein.",

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AU - Wheelock, Margaret J.

AU - Wahl, James K.

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Generation and characterization of monoclonal antibodies against the proregion of human desmoglein-2

Abstract

ASJC Scopus subject areas

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