@inbook{9fa6a462b0c948fdb72eaa6055bfc1e6,
title = "Generation of a central nervous system catheter-associated infection in mice with Staphylococcus epidermidis",
abstract = "Animal models are valuable tools for investigating the in vivo pathogenesis of Staphylococcus epidermidis infections. Here, we present the procedure for generating a central nervous system catheter-associated infection in a mouse, to model the central nervous system shunt infections that frequently complicate the treatment of hydrocephalus in humans. This model uses stereotactic guidance to place silicone catheters, pre-coated with S. epidermidis, into the lateral ventricles of mice. This results in a catheter-associated infection in the brain, with concomitant illness and inflammation. This animal model is a valuable tool for evaluating the pathogenesis of bacterial infection in the central nervous system, the immune response to these infections and potential treatment options.",
keywords = "Catheter infection, Central nervous system, Mouse model, Shunt infection",
author = "Snowden, {Jessica N.}",
year = "2014",
doi = "10.1007/978-1-62703-736-5_18",
language = "English (US)",
isbn = "9781627037358",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "193--198",
booktitle = "Staphylococcus Epidermidis",
}