Generation of osteoporosis in immune-compromised mice for stem cell therapy

Reeva Aggarwal, Vincent J. Pompili, Hiranmoy Das

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


To evaluate therapeutic efficacy and to investigate involved molecular mechanisms of cell-based therapy in osteoporosis, the generation of a clinically relevant model is critically important. Herein, we describe detailed methods in generation of an immune-deficient osteoporotic murine model, and application of human umbilical cord blood-derived stem cells to assess their therapeutic efficacy.

Original languageEnglish (US)
Pages (from-to)209-214
Number of pages6
JournalMethods in Molecular Biology
StatePublished - 2014


  • Intramyocardial injection
  • NOD/SCID mice
  • Osteoporosis
  • Stem cells

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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