Abstract
To evaluate therapeutic efficacy and to investigate involved molecular mechanisms of cell-based therapy in osteoporosis, the generation of a clinically relevant model is critically important. Herein, we describe detailed methods in generation of an immune-deficient osteoporotic murine model, and application of human umbilical cord blood-derived stem cells to assess their therapeutic efficacy.
Original language | English (US) |
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Pages (from-to) | 209-214 |
Number of pages | 6 |
Journal | Methods in Molecular Biology |
Volume | 1213 |
DOIs | |
State | Published - 2014 |
Externally published | Yes |
Keywords
- Intramyocardial injection
- NOD/SCID mice
- Osteoporosis
- Stem cells
ASJC Scopus subject areas
- Molecular Biology
- Genetics