Genetic and clinical features of sensorineural hearing loss associated with the 1555 mitochondrial mutation

Shin Ichi Usami; Satoko Abe; Miyo Kasai; Hideichi Shinkawa; Benjamin Moeller; Judy B. Kenyon; William J. Kimberling

doi:10.1097/00005537-199704000-00011

Genetic and clinical features of sensorineural hearing loss associated with the 1555 mitochondrial mutation

Shin Ichi Usami, Satoko Abe, Miyo Kasai, Hideichi Shinkawa, Benjamin Moeller, Judy B. Kenyon, William J. Kimberling

Center for Sensory Neuroscience

Research output: Contribution to journal › Article › peer-review

129 Scopus citations

Abstract

Five Japanese families showing aminoglycoside-induced hearing loss were genetically as well as clinically investigated. A mitochondrial mutation at nucleotide 1555 was found in 28 out of 32 subjects. One hundred American control subjects did not show any evidence of the mutation at nucleotide 1555, suggesting that the 1555 A→G (A1555G) mitochondrial mutation may be found more frequently among populations in the Asian continent. Many subjects who harbor this mitochondrial mutation exhibit a mild, high-frequency, progressive hearing loss even without aminoglycoside injection. The resuits presented here appear to support the hypothesis that the A1555G mutation may play a more general role in causing hearing loss.

Original language	English (US)
Pages (from-to)	483-490
Number of pages	8
Journal	Laryngoscope
Volume	107
Issue number	4
DOIs	https://doi.org/10.1097/00005537-199704000-00011
State	Published - Apr 1997

ASJC Scopus subject areas

Otorhinolaryngology

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title = "Genetic and clinical features of sensorineural hearing loss associated with the 1555 mitochondrial mutation",

abstract = "Five Japanese families showing aminoglycoside-induced hearing loss were genetically as well as clinically investigated. A mitochondrial mutation at nucleotide 1555 was found in 28 out of 32 subjects. One hundred American control subjects did not show any evidence of the mutation at nucleotide 1555, suggesting that the 1555 A→G (A1555G) mitochondrial mutation may be found more frequently among populations in the Asian continent. Many subjects who harbor this mitochondrial mutation exhibit a mild, high-frequency, progressive hearing loss even without aminoglycoside injection. The resuits presented here appear to support the hypothesis that the A1555G mutation may play a more general role in causing hearing loss.",

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AU - Usami, Shin Ichi

AU - Abe, Satoko

AU - Kasai, Miyo

AU - Shinkawa, Hideichi

AU - Moeller, Benjamin

AU - Kenyon, Judy B.

AU - Kimberling, William J.

PY - 1997/4

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N2 - Five Japanese families showing aminoglycoside-induced hearing loss were genetically as well as clinically investigated. A mitochondrial mutation at nucleotide 1555 was found in 28 out of 32 subjects. One hundred American control subjects did not show any evidence of the mutation at nucleotide 1555, suggesting that the 1555 A→G (A1555G) mitochondrial mutation may be found more frequently among populations in the Asian continent. Many subjects who harbor this mitochondrial mutation exhibit a mild, high-frequency, progressive hearing loss even without aminoglycoside injection. The resuits presented here appear to support the hypothesis that the A1555G mutation may play a more general role in causing hearing loss.

AB - Five Japanese families showing aminoglycoside-induced hearing loss were genetically as well as clinically investigated. A mitochondrial mutation at nucleotide 1555 was found in 28 out of 32 subjects. One hundred American control subjects did not show any evidence of the mutation at nucleotide 1555, suggesting that the 1555 A→G (A1555G) mitochondrial mutation may be found more frequently among populations in the Asian continent. Many subjects who harbor this mitochondrial mutation exhibit a mild, high-frequency, progressive hearing loss even without aminoglycoside injection. The resuits presented here appear to support the hypothesis that the A1555G mutation may play a more general role in causing hearing loss.

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Genetic and clinical features of sensorineural hearing loss associated with the 1555 mitochondrial mutation

Abstract

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