Genetic Code Expansion Through Quadruplet Codon Decoding

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Noncanonical amino acid mutagenesis has emerged as a powerful tool for the study of protein structure and function. While triplet nonsense codons, especially the amber codon, have been widely employed, quadruplet codons have attracted attention for the potential of creating additional blank codons for noncanonical amino acids mutagenesis. In this review, we discuss methodologies and applications of quadruplet codon decoding in genetic code expansion both in vitro and in vivo.

Original languageEnglish (US)
Article number167346
JournalJournal of Molecular Biology
Volume434
Issue number8
DOIs
StatePublished - Apr 30 2022
Externally publishedYes

Keywords

  • +1 frameshift
  • four-base codon
  • genetic code
  • non-canonical amino acids
  • quadruplet codon

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Molecular Biology

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