Genetic determinants of drug response in heart failure

Brian D. Lowes, Peter M. Buttrick

Research output: Contribution to journalArticlepeer-review

Abstract

Heart failure management is complex and costly. Genetic variations that alter drug absorption, metabolism, and receptor-ligand interactions have the potential to modify drug response and safety. Evidence shows that genetic factors interact with numerous heart failure medications, including vasodilators, β blockers, and angiotensin-converting enzyme inhibitors. Technologic advances will soon allow population-based genomewide genetic testing at a reasonable cost. Understanding the genetic factors that influence drug response in heart failure will allow physicians to personalize therapies and optimize response while minimizing serious adverse events.

Original languageEnglish (US)
Pages (from-to)485-490
Number of pages6
JournalCurrent Cardiovascular Risk Reports
Volume2
Issue number6
DOIs
StatePublished - 2008

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Genetic determinants of drug response in heart failure'. Together they form a unique fingerprint.

Cite this