Genetic determinants of drug response in heart failure

Brian D. Lowes, Peter M. Buttrick

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Heart failure management is complex and costly. Genetic variations that alter drug absorption, metabolism, and receptor-ligand interactions have the potential to modify drug response and safety. Evidence shows that genetic factors interact with numerous heart failure medications, including vasodilators, β blockers, and angiotensin-converting enzyme inhibitors. Technologic advances will soon allow population-based genome-wide genetic testing at a reasonable cost. Understanding the genetic factors that influence drug response in heart failure will allow physicians to personalize therapies and optimize response while minimizing serious adverse events.

Original languageEnglish (US)
Pages (from-to)176-181
Number of pages6
JournalCurrent Cardiology Reports
Volume10
Issue number3
DOIs
StatePublished - 2008
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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