Genetic encoding of a nonhydrolyzable phosphotyrosine analog in mammalian cells

Xinyuan He, Bin Ma, Yan Chen, Jiantao Guo, Wei Niu

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Protein tyrosine phosphorylation plays a critical role in signal transduction. We report the genetic incorporation of a phosphotyrosine (pTyr) analog, p-carboxymethyl-l-phenylalanine (CMF), into proteins in mammalian cells. This nonhydrolyzable pTyr analog can facilitate biological studies by removing complications caused by the dynamic interconversion between the phosphorylated and non-phosphorylated isoforms of a protein.

Original languageEnglish (US)
JournalChemical Communications
DOIs
StateAccepted/In press - 2022

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • General Chemistry
  • Ceramics and Composites
  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Catalysis

Fingerprint

Dive into the research topics of 'Genetic encoding of a nonhydrolyzable phosphotyrosine analog in mammalian cells'. Together they form a unique fingerprint.

Cite this