Genetic encoding of a nonhydrolyzable phosphotyrosine analog in mammalian cells

Xinyuan He, Bin Ma, Yan Chen, Jiantao Guo, Wei Niu

Research output: Contribution to journalArticlepeer-review

Abstract

Protein tyrosine phosphorylation plays a critical role in signal transduction. We report the genetic incorporation of a phosphotyrosine (pTyr) analog, p-carboxymethyl-l-phenylalanine (CMF), into proteins in mammalian cells. This nonhydrolyzable pTyr analog can facilitate biological studies by removing complications caused by the dynamic interconversion between the phosphorylated and non-phosphorylated isoforms of a protein.

Original languageEnglish (US)
JournalChemical Communications
DOIs
StateAccepted/In press - 2022

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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