Genetic modification of somatic cells for producing animal models and for cellular transplantation

Research output: Contribution to journalArticle

Abstract

Great progress has been made in two technologies related to biomedical research: (1) manipulating the genomes of cells; and (2) inducing stem cells in culture to differentiate into potentially useful cell types. These technologies can be used to create animal models of human disease and to provide cells for transplantation to ameliorate human disease. Both embryonic stem cells and adult stem cells have been studied for these purposes. Genetically modified somatic cells provide another source of cells for creating animal models and for cellular transplantation.

Original languageEnglish (US)
Pages (from-to)811-815
Number of pages5
JournalReproduction, Fertility and Development
Volume18
Issue number8
DOIs
StatePublished - Nov 29 2006

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Keywords

  • Dedifferentiation
  • Hypoxanthine guanine phosphoribosyl transferase
  • Lesch-Nyhan's disease
  • Non-human primate
  • Stem gene targeting

ASJC Scopus subject areas

  • Biotechnology
  • Reproductive Medicine
  • Animal Science and Zoology
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Developmental Biology

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