Abstract
Great progress has been made in two technologies related to biomedical research: (1) manipulating the genomes of cells; and (2) inducing stem cells in culture to differentiate into potentially useful cell types. These technologies can be used to create animal models of human disease and to provide cells for transplantation to ameliorate human disease. Both embryonic stem cells and adult stem cells have been studied for these purposes. Genetically modified somatic cells provide another source of cells for creating animal models and for cellular transplantation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 811-815 |
| Number of pages | 5 |
| Journal | Reproduction, Fertility and Development |
| Volume | 18 |
| Issue number | 8 |
| DOIs | |
| State | Published - 2006 |
Keywords
- Dedifferentiation
- Hypoxanthine guanine phosphoribosyl transferase
- Lesch-Nyhan's disease
- Non-human primate
- Stem gene targeting
ASJC Scopus subject areas
- Biotechnology
- Reproductive Medicine
- Animal Science and Zoology
- Molecular Biology
- Genetics
- Endocrinology
- Developmental Biology