Genetic variants and susceptibility to neurological complications following West Nile virus infection

Mark Loeb, Sasha Eskandarian, Mark Rupp, Neil Fishman, Leanne Gasink, Jan Patterson, Jonathan Bramson, Thomas J. Hudson, Mathieu Lemire

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

To determine genetic factors predisposing to neurological complications following West Nile virus infection, we analyzed a cohort of 560 neuroinvasive case patients and 950 control patients for 13 371 mostly nonsynonymous single-nucleotide polymorphisms (SNPs). The top 3 SNPs on the basis of statistical significance were also in genes of biological plausibility: rs2066786 in RFC1 (replication factor C1) (P= 1.88×10-5; odds ratio [OR], 0.68 [95% confidence interval {CI}, .56-.81]); rs2298771 in SCN1A (sodium channel, neuronal type I a subunit) (P = 5.87 × 10-5; OR, 1.47 [95% CI, 1.21-1.77]); and rs25651 in ANPEP (ananyl aminopeptidase) (P = 1.44 × 10-4; OR, 0.69 [95% CI, .56-.83]). Additional genotyping of these SNPs in a separate sample of 264 case patients and 296 control patients resulted in a lack of significance in the replication cohort; joint significance was as follows: rs2066786, P = .0022; rs2298771, P = .005; rs25651, P = .042. Using mostly nonsynonymous variants, we therefore did not identify genetic variants associated with neuroinvasive disease.

Original languageEnglish (US)
Pages (from-to)1031-1037
Number of pages7
JournalJournal of Infectious Diseases
Volume204
Issue number7
DOIs
StatePublished - Oct 1 2011

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Genetic variants and susceptibility to neurological complications following West Nile virus infection'. Together they form a unique fingerprint.

  • Cite this

    Loeb, M., Eskandarian, S., Rupp, M., Fishman, N., Gasink, L., Patterson, J., Bramson, J., Hudson, T. J., & Lemire, M. (2011). Genetic variants and susceptibility to neurological complications following West Nile virus infection. Journal of Infectious Diseases, 204(7), 1031-1037. https://doi.org/10.1093/infdis/jir493