Genetic variation in the Yolk protein expression network of Drosophila melanogaster: Sex-biased negative correlations with longevity

A. M. Tarone, L. M. McIntyre, L. G. Harshman, S. V. Nuzhdin

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

One of the persistent problems in biology is understanding how genetic variation contributes to phenotypic variation. Associations at many levels have been reported, and yet causal inference has remained elusive. We propose to rely on the knowledge of causal relationships established by molecular biology approaches. The existing molecular knowledge forms a firm backbone upon which hypotheses connecting genetic variation, transcriptional variation and phenotypic variation can be built. The sex determination pathway is a well-established molecular network, with the Yolk protein 1-3 (Yp) genes as the most downstream target. Our analyses reveal that genetic variation in expression for genes known to be upstream in the pathway explains variation in downstream targets. Relationships differ between the two sexes, and each Yp has a distinct transcriptional pattern. Yp expression is significantly negatively correlated with longevity, an important life history trait, for both males and females.

Original languageEnglish (US)
Pages (from-to)226-234
Number of pages9
JournalHeredity
Volume109
Issue number4
DOIs
StatePublished - Oct 2012

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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