TY - JOUR
T1 - Genetically engineered mucin mouse models for inflammation and cancer
AU - Joshi, Suhasini
AU - Kumar, Sushil
AU - Bafna, Sangeeta
AU - Rachagani, Satyanarayana
AU - Wagner, Kay Uwe
AU - Jain, Maneesh
AU - Batra, Surinder K.
N1 - Publisher Copyright:
© 2015, Springer Science+Business Media New York.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Mucins are heavily O-glycosylated proteins primarily produced by glandular and ductal epithelial cells, either in membrane-tethered or secretory forms, for providing lubrication and protection from various exogenous and endogenous insults. However, recent studies have linked their aberrant overexpression with infection, inflammation, and cancer that underscores their importance in tissue homeostasis. In this review, we present current status of the existing mouse models that have been developed to gain insights into the functional role(s) of mucins under physiological and pathological conditions. Knockout mouse models for membrane-associated (Muc1 and Muc16) and secretory mucins (Muc2) have helped us to elucidate the role of mucins in providing effective and protective barrier functions against pathological threats, participation in disease progression, and improved our understanding of mucin interaction with biotic and abiotic environmental components. Emphasis is also given to available transgenic mouse models (MUC1 and MUC7), which has been exploited to understand the context-dependent regulation and therapeutic potential of human mucins during inflammation and cancer.
AB - Mucins are heavily O-glycosylated proteins primarily produced by glandular and ductal epithelial cells, either in membrane-tethered or secretory forms, for providing lubrication and protection from various exogenous and endogenous insults. However, recent studies have linked their aberrant overexpression with infection, inflammation, and cancer that underscores their importance in tissue homeostasis. In this review, we present current status of the existing mouse models that have been developed to gain insights into the functional role(s) of mucins under physiological and pathological conditions. Knockout mouse models for membrane-associated (Muc1 and Muc16) and secretory mucins (Muc2) have helped us to elucidate the role of mucins in providing effective and protective barrier functions against pathological threats, participation in disease progression, and improved our understanding of mucin interaction with biotic and abiotic environmental components. Emphasis is also given to available transgenic mouse models (MUC1 and MUC7), which has been exploited to understand the context-dependent regulation and therapeutic potential of human mucins during inflammation and cancer.
KW - Cancer
KW - Knockout models
KW - Mucins
KW - Synteny
KW - Transgenic mice models
KW - Vaccines
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U2 - 10.1007/s10555-015-9549-1
DO - 10.1007/s10555-015-9549-1
M3 - Review article
C2 - 25634251
AN - SCOPUS:84958831818
SN - 0167-7659
VL - 34
SP - 593
EP - 609
JO - Cancer and Metastasis Reviews
JF - Cancer and Metastasis Reviews
IS - 4
ER -