Genetics of coxsackievirus B cardiovirulence and inflammatory heart muscle disease

Steven Tracy, Nora M. Chapman, José Romero, Arlene I. Ramsingh

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

Coxsackieviruses B (CVBs) are etiological agents of human inflammatory myocardial disease. The genetics of the coxsackieviral virulence phenotype in mice are now beginning to be understood with the availability of infectious cDNA copies of CVB genomes. Investigations to date with CVB3 and CVB4 have shown that sites within a non-translated region and in the capsid proteins can affect the virulence phenotype. The relative importance of these sites to expression of the phenotype remains unclear.

Original languageEnglish (US)
Pages (from-to)175-179
Number of pages5
JournalTrends in Microbiology
Volume4
Issue number5
DOIs
StatePublished - May 1996

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

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