Genetics of coxsackievirus B cardiovirulence and inflammatory heart muscle disease

Steven Tracy; Nora M. Chapman; José Romero; Arlene I. Ramsingh

doi:10.1016/0966-842X(96)10026-3

Genetics of coxsackievirus B cardiovirulence and inflammatory heart muscle disease

Steven Tracy, Nora M. Chapman, José Romero, Arlene I. Ramsingh

Pathology & Microbiology

Research output: Contribution to journal › Review article › peer-review

32 Scopus citations

Abstract

Coxsackieviruses B (CVBs) are etiological agents of human inflammatory myocardial disease. The genetics of the coxsackieviral virulence phenotype in mice are now beginning to be understood with the availability of infectious cDNA copies of CVB genomes. Investigations to date with CVB3 and CVB4 have shown that sites within a non-translated region and in the capsid proteins can affect the virulence phenotype. The relative importance of these sites to expression of the phenotype remains unclear.

Original language	English (US)
Pages (from-to)	175-179
Number of pages	5
Journal	Trends in Microbiology
Volume	4
Issue number	5
DOIs	https://doi.org/10.1016/0966-842X(96)10026-3
State	Published - May 1996

ASJC Scopus subject areas

Microbiology
Microbiology (medical)
Infectious Diseases
Virology

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title = "Genetics of coxsackievirus B cardiovirulence and inflammatory heart muscle disease",

abstract = "Coxsackieviruses B (CVBs) are etiological agents of human inflammatory myocardial disease. The genetics of the coxsackieviral virulence phenotype in mice are now beginning to be understood with the availability of infectious cDNA copies of CVB genomes. Investigations to date with CVB3 and CVB4 have shown that sites within a non-translated region and in the capsid proteins can affect the virulence phenotype. The relative importance of these sites to expression of the phenotype remains unclear.",

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T1 - Genetics of coxsackievirus B cardiovirulence and inflammatory heart muscle disease

AU - Tracy, Steven

AU - Chapman, Nora M.

AU - Romero, José

AU - Ramsingh, Arlene I.

PY - 1996/5

Y1 - 1996/5

N2 - Coxsackieviruses B (CVBs) are etiological agents of human inflammatory myocardial disease. The genetics of the coxsackieviral virulence phenotype in mice are now beginning to be understood with the availability of infectious cDNA copies of CVB genomes. Investigations to date with CVB3 and CVB4 have shown that sites within a non-translated region and in the capsid proteins can affect the virulence phenotype. The relative importance of these sites to expression of the phenotype remains unclear.

AB - Coxsackieviruses B (CVBs) are etiological agents of human inflammatory myocardial disease. The genetics of the coxsackieviral virulence phenotype in mice are now beginning to be understood with the availability of infectious cDNA copies of CVB genomes. Investigations to date with CVB3 and CVB4 have shown that sites within a non-translated region and in the capsid proteins can affect the virulence phenotype. The relative importance of these sites to expression of the phenotype remains unclear.

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U2 - 10.1016/0966-842X(96)10026-3

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JO - Trends in Microbiology

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ER -

Genetics of coxsackievirus B cardiovirulence and inflammatory heart muscle disease

Abstract

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