Genetics of coxsackievirus B3 cardiovirulence

S. Tracy; Z. Tu; N. Chapman; G. Hufnagel

doi:10.1093/eurheartj/16.suppl_o.15

Genetics of coxsackievirus B3 cardiovirulence

S. Tracy, Z. Tu, N. Chapman, G. Hufnagel

Pathology & Microbiology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The human enteroviruses, especially the coxsackie B viruses, have been established as aetiologic agents of human inflammatory heart disease, a condition which may lead to dilated cardiomyopathy and heart failure. It is clear from murine models of coxsackievirus B3-induced inflammatory heart disease that not all strains of the virus are cardiovirulent (able to cause disease). Here, we present preliminary data mapping the site in a coxsackievirus B3 genome which determines a cardiovirulent phenotype.

Original language	English (US)
Pages (from-to)	15-17
Number of pages	3
Journal	European Heart Journal
Volume	16
Issue number	SUPPL. O
DOIs	https://doi.org/10.1093/eurheartj/16.suppl_o.15
State	Published - 1995

Keywords

Coxsackievirus B3
Enterovirus
Inflammatory heart disease

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1093/eurheartj/16.suppl_o.15

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AB - The human enteroviruses, especially the coxsackie B viruses, have been established as aetiologic agents of human inflammatory heart disease, a condition which may lead to dilated cardiomyopathy and heart failure. It is clear from murine models of coxsackievirus B3-induced inflammatory heart disease that not all strains of the virus are cardiovirulent (able to cause disease). Here, we present preliminary data mapping the site in a coxsackievirus B3 genome which determines a cardiovirulent phenotype.

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Genetics of coxsackievirus B3 cardiovirulence

Abstract

Keywords

ASJC Scopus subject areas

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