Genetics of coxsackievirus B3 cardiovirulence

S. Tracy, Z. Tu, N. Chapman, G. Hufnagel

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The human enteroviruses, especially the coxsackie B viruses, have been established as aetiologic agents of human inflammatory heart disease, a condition which may lead to dilated cardiomyopathy and heart failure. It is clear from murine models of coxsackievirus B3-induced inflammatory heart disease that not all strains of the virus are cardiovirulent (able to cause disease). Here, we present preliminary data mapping the site in a coxsackievirus B3 genome which determines a cardiovirulent phenotype.

Original languageEnglish (US)
Pages (from-to)15-17
Number of pages3
JournalEuropean Heart Journal
Volume16
Issue numberSUPPL. O
DOIs
StatePublished - 1995

Keywords

  • Coxsackievirus B3
  • Enterovirus
  • Inflammatory heart disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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