Genital ulcers facilitate rapid viral entry and dissemination following intravaginal inoculation with cell-associated simian immunodeficiency virus SIVmac239

Andrea M. Weiler, Qingsheng Li, Lijie Duan, Masahiko Kaizu, Kim L. Weisgrau, Thomas C. Friedrich, Matthew R. Reynolds, Ashley T. Haase, Eva G. Rakasz

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Here we report the results of studies in the simian immunodeficiency virus (SIV)-rhesus macaque model of intravaginal transmission of human immunodeficiency virus type 1 in the setting of genital ulcerative diseases. We document preferential association of vRNA with induced ulcers during the first days of infection and show that allogeneic cells of the inoculum traffic from the vaginal lumen to lymphatic tissues. This surprisingly rapid systemic dissemination in this cell-associated SIV challenge model thus reveals the challenges of preventing transmission in the setting of genital ulcerative diseases and illustrates the utility of this animal model in tests of strategies aimed at reducing transmission under these conditions.

Original languageEnglish (US)
Pages (from-to)4154-4158
Number of pages5
JournalJournal of virology
Volume82
Issue number8
DOIs
StatePublished - Apr 1 2008

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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    Weiler, A. M., Li, Q., Duan, L., Kaizu, M., Weisgrau, K. L., Friedrich, T. C., Reynolds, M. R., Haase, A. T., & Rakasz, E. G. (2008). Genital ulcers facilitate rapid viral entry and dissemination following intravaginal inoculation with cell-associated simian immunodeficiency virus SIVmac239. Journal of virology, 82(8), 4154-4158. https://doi.org/10.1128/JVI.01947-07