Genitourinary health in a population-based cohort of males with Duchenne and Becker Muscular dystrophies

The Muscular Dystrophy Surveillance, Tracking, and Research Network

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Introduction: Genitourinary (GU) health among patients with Duchenne and Becker muscular dystrophies (DBMD) has not been explored using population-based data. Methods: Medical records of 918 males ascertained by the Muscular Dystrophy Surveillance, Tracking, and Research Network were reviewed for documentation of GU-related hospitalizations and prescribed medications. Percentages of males who received these medical interventions were calculated, and hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for associations with sociodemographics (study site, race/ethnicity), symptoms (early- vs. late-onset, ambulation status, scoliosis), and treatments (respiratory support, steroids). Results: Among the 918 males, 81 (9%) had a GU condition, with voiding dysfunction (n=40), GU tract infection (n=19), and kidney/ureter calculus (n=9) most frequently seen. The Kaplan-Meier curve produced a cumulative probability of 27%. Cox regression showed GU conditions were more common when males were non-ambulatory (HR 2.7, 95% CI 1.3-5.6). Conclusions: Our findings highlight the need for increased awareness of GU health and multidisciplinary care of DBMD patients.

Original languageEnglish (US)
Pages (from-to)22-27
Number of pages6
JournalMuscle and Nerve
Volume52
Issue number1
DOIs
StatePublished - Jul 1 2015
Externally publishedYes

Keywords

  • Becker muscular dystrophy
  • Duchenne muscular dystrophy
  • Epidemiology
  • Male urogenital diseases
  • Neuromuscular diseases

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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