TY - JOUR
T1 - Genitourinary health in a population-based cohort of males with Duchenne and Becker Muscular dystrophies
AU - The Muscular Dystrophy Surveillance, Tracking, and Research Network
AU - Zhu, Yong
AU - Romitti, Paul A.
AU - Caspers Conway, Kristin M.
AU - Kim, Sunkyung
AU - Zhang, Ying
AU - Yang, Michele
AU - Mathews, Katherine D.
N1 - Publisher Copyright:
© 2014 Wiley Periodicals, Inc.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Introduction: Genitourinary (GU) health among patients with Duchenne and Becker muscular dystrophies (DBMD) has not been explored using population-based data. Methods: Medical records of 918 males ascertained by the Muscular Dystrophy Surveillance, Tracking, and Research Network were reviewed for documentation of GU-related hospitalizations and prescribed medications. Percentages of males who received these medical interventions were calculated, and hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for associations with sociodemographics (study site, race/ethnicity), symptoms (early- vs. late-onset, ambulation status, scoliosis), and treatments (respiratory support, steroids). Results: Among the 918 males, 81 (9%) had a GU condition, with voiding dysfunction (n=40), GU tract infection (n=19), and kidney/ureter calculus (n=9) most frequently seen. The Kaplan-Meier curve produced a cumulative probability of 27%. Cox regression showed GU conditions were more common when males were non-ambulatory (HR 2.7, 95% CI 1.3-5.6). Conclusions: Our findings highlight the need for increased awareness of GU health and multidisciplinary care of DBMD patients.
AB - Introduction: Genitourinary (GU) health among patients with Duchenne and Becker muscular dystrophies (DBMD) has not been explored using population-based data. Methods: Medical records of 918 males ascertained by the Muscular Dystrophy Surveillance, Tracking, and Research Network were reviewed for documentation of GU-related hospitalizations and prescribed medications. Percentages of males who received these medical interventions were calculated, and hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for associations with sociodemographics (study site, race/ethnicity), symptoms (early- vs. late-onset, ambulation status, scoliosis), and treatments (respiratory support, steroids). Results: Among the 918 males, 81 (9%) had a GU condition, with voiding dysfunction (n=40), GU tract infection (n=19), and kidney/ureter calculus (n=9) most frequently seen. The Kaplan-Meier curve produced a cumulative probability of 27%. Cox regression showed GU conditions were more common when males were non-ambulatory (HR 2.7, 95% CI 1.3-5.6). Conclusions: Our findings highlight the need for increased awareness of GU health and multidisciplinary care of DBMD patients.
KW - Becker muscular dystrophy
KW - Duchenne muscular dystrophy
KW - Epidemiology
KW - Male urogenital diseases
KW - Neuromuscular diseases
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U2 - 10.1002/mus.24486
DO - 10.1002/mus.24486
M3 - Article
C2 - 25297835
AN - SCOPUS:84931577637
SN - 0148-639X
VL - 52
SP - 22
EP - 27
JO - Muscle and Nerve
JF - Muscle and Nerve
IS - 1
ER -