Genome-wide search for host association factors during ovine progressive pneumonia virus infection

Jesse Thompson, Fangrui Ma, Meghan Quinn, Shi Hua Xiang

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Ovine progressive pneumonia virus (OPPV) is an important virus that causes serious diseases in sheep and goats with a prevalence of 36% in the USA. Although OPPV was discovered more than half of a century ago, little is known about the infection and pathogenesis of this virus. In this report, we used RNA-seq technology to conduct a genome-wide probe for cellular factors that are associated with OPPV infection. A total of approximately 22,000 goat host genes were detected of which 657 were found to have been significantly up-regulated and 889 down-regulated at 12 hours post-infection. In addition to previously known restriction factors from other viral infections, a number of factors which may be specific for OPPV infection were uncovered. The data from this RNA-seq study will be helpful in our understanding of OPPV infection, and also for further study in the prevention and intervention of this viral disease.

Original languageEnglish (US)
Article numbere0150344
JournalPloS one
Volume11
Issue number3
DOIs
StatePublished - Mar 2016

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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