TY - JOUR
T1 - Genome-wide signatures of mammalian skin covering evolution
AU - Cao, Peng
AU - Dai, Qinlong
AU - Deng, Cao
AU - Zhao, Xiang
AU - Qin, Shishan
AU - Yang, Jian
AU - Ju, Ran
AU - Wang, Zhiwen
AU - Lu, Guoqing
AU - Gu, Xiaodong
AU - Yang, Zhisong
AU - Zhu, Lifeng
N1 - Funding Information:
This work was supported by the National Natural Science Fund for Outstanding Youth Fund (31222009, 31272295, 31570489, 81622048 and 81473377), the Project of Quality Guarantee System of Chinese Herbal Medicines (201507002), Science Foundation for Distinguished Young Scholars of Jiangsu Province (BK20140049) and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).
Publisher Copyright:
© 2021, Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2021/10
Y1 - 2021/10
N2 - Animal body coverings provide protection and allow for adaptation to environmental pressures such as heat, ultraviolet radiation, water loss, and mechanical forces. Here, using a comparative genomics analysis of 39 mammal species spanning three skin covering types (hairless, scaly and spiny), we found some genes (e.g., UVRAG, POLH, and XPC) involved in skin inflammation, skin innate immunity, and ultraviolet radiation damage repair were under selection in hairless ocean mammals (e.g., whales and manatees). These signatures might be associated with a high risk of skin diseases from pathogens and ultraviolet radiation. Moreover, the genomes from three spiny mammal species shared convergent genomic regions (EPHB2, EPHA4, and NIN) and unique positively selected genes (FZD6, INVS, and CDC42) involved in skin cell polarity, which might be related to the development of spines. In scaly mammals, the shared convergent genomic regions (e.g., FREM2) were associated with the integrity of the skin epithelium and epidermal adhesion. This study identifies potential convergent genomic features among distantly related mammals with the same skin covering type.
AB - Animal body coverings provide protection and allow for adaptation to environmental pressures such as heat, ultraviolet radiation, water loss, and mechanical forces. Here, using a comparative genomics analysis of 39 mammal species spanning three skin covering types (hairless, scaly and spiny), we found some genes (e.g., UVRAG, POLH, and XPC) involved in skin inflammation, skin innate immunity, and ultraviolet radiation damage repair were under selection in hairless ocean mammals (e.g., whales and manatees). These signatures might be associated with a high risk of skin diseases from pathogens and ultraviolet radiation. Moreover, the genomes from three spiny mammal species shared convergent genomic regions (EPHB2, EPHA4, and NIN) and unique positively selected genes (FZD6, INVS, and CDC42) involved in skin cell polarity, which might be related to the development of spines. In scaly mammals, the shared convergent genomic regions (e.g., FREM2) were associated with the integrity of the skin epithelium and epidermal adhesion. This study identifies potential convergent genomic features among distantly related mammals with the same skin covering type.
KW - comparative genomics
KW - convergent evolution
KW - hairless mammals
KW - scaly mammals
KW - skin coverings
KW - spiny mammals
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U2 - 10.1007/s11427-020-1841-5
DO - 10.1007/s11427-020-1841-5
M3 - Article
C2 - 33481165
AN - SCOPUS:85099971406
SN - 1674-7305
VL - 64
SP - 1765
EP - 1780
JO - Science China Life Sciences
JF - Science China Life Sciences
IS - 10
ER -