Genomic aberrations affecting the outcome of immunodeficiency-related diffuse large B-cell lymphoma

Ivo Kwee, Daniela Capello, Andrea Rinaldi, Paola M.V. Rancoita, Govind Bhagat, Tim C. Greiner, Michele Spina, Annunziata Gloghini, Wing C. Chan, Marco Paulli, Emanuele Zucca, Umberto Tirelli, Antonino Carbone, Gianluca Gaidano, Francesco Bertoni

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The objective of this study was to evaluate the prognostic impact of genomic regions in a series of human immunodeficiency virus (HIV)-related diffuse large B-cell lymphomas (HIV-DLBCLs) and post-transplant DLBCLs (PT-DLBCLs) analyzed by genome-wide DNA profiling. Minimal common regions (MCRs) were estimated on genomic profiles obtained using Affymetrix Human Mapping 250k Nsp I arrays and tested for their impact on clinical outcome by univariate analysis on 36 PT-DLBCLs, 19 HIV-DLBCLs and, as a control group, 149 DLBCLs arising in immunocompetent individuals (IC-DLBCLs). PT-DLBCL and HIV-DLBCL presented a similar outcome. Immunodeficiency-related DLBCL (ID-DLBCL) had a worse overall survival (OS) than IC-DLBCL. Seven MCRs showed a statistical impact on OS in PT-DLBCL and four in HIV-DLBCL. Among these, the presence of gains at 1q or at 18q defined a group of patients with PT-DLBCL with a very poor outcome (p < 0.0001). The presence of del(3p14.2) or of + 2p23.1 identified a group of HIV-DLBCLs with a very poor outcome (p = 0.0072). It was concluded that genomic aberrations affecting outcome differ between ID-DLBCL and IC-DLBCL and are also dependent on the type of acquired immunodeficiency.

Original languageEnglish (US)
Pages (from-to)71-76
Number of pages6
JournalLeukemia and Lymphoma
Issue number1
StatePublished - Jan 2012


  • Diffuse large B-cell lymphoma
  • FHIT
  • HIV
  • Immunodeficiency
  • Lymphoma
  • Organ transplant
  • Outcome

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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