Genomic lesions associated with a different clinical outcome in diffuse large B-cell lymphoma treated with R-CHOP-21

Marta Scandurra, Michael Mian, Timothy C. Greiner, Paola M.V. Rancoita, Cassio P. De Campos, Wing C. Chan, Julie M. Vose, Ekaterina Chigrinova, Giorgio Inghirami, Annalisa Chiappella, Luca Baldini, Maurilio Ponzoni, Andres J.M. Ferreri, Silvia Franceschetti, Gianluca Gaidano, Santiago Montes-Moreno, Miguel A. Piris, Fabio Facchetti, Alessandra Tucci, Josep Fr NomdedeuThierry Lazure, Olivier Lambotte, Silvia Uccella, Graziella Pinotti, Giancarlo Pruneri, Giovanni Martinelli, Ken H. Young, Maria Grazia Tibiletti, Andrea Rinaldi, Emanuele Zucca, Ivo Kwee, Francesco Bertoni

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Despite recent therapeutic improvements, the clinical course of diffuse large B-cell lymphoma (DLBCL) still differs considerably among patients. We conducted this retrospective multi-centre study to evaluate the impact of genomic aberrations detected using a high-density genome wide-single nucleotide polymorphism-based array on clinical outcome in a population of DLBCL patients treated with R-CHOP-21 (rituximab, cyclophosphamide, doxorubicine, vincristine and prednisone repeated every 21 d). 166 DNA samples were analysed using the GeneChip Human Mapping 250K NspI. Genomic anomalies were analysed regarding their impact on the clinical course of 124 patients treated with R-CHOP-21. Unsupervised clustering was performed to identify genetically related subgroups of patients with different clinical outcomes. Twenty recurrent genetic lesions showed an impact on the clinical course. Loss of genomic material at 8p23.1 showed the strongest statistical significance and was associated with additional aberrations, such as 17p- and 15q-. Unsupervised clustering identified five DLBCL clusters with distinct genetic profiles, clinical characteristics and outcomes. Genetic features and clusters, associated with a different outcome in patients treated with R-CHOP, have been identified by arrayCGH.

Original languageEnglish (US)
Pages (from-to)221-231
Number of pages11
JournalBritish Journal of Haematology
Volume151
Issue number3
DOIs
StatePublished - Nov 2010

Keywords

  • Comparative genomic hybridization
  • Hepatitis C virus
  • Lymphoma
  • Microarray
  • Prognosis

ASJC Scopus subject areas

  • Hematology

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