Ketamine, a non-barbiturate anaesthetic agent, was studied for its genotoxic potential using the SCE assay. It was genotoxic in the in vitro system at concentrations comparable to the plasma levels achieved during steady state anaesthesia. It had no effects on cellular kinetics in CHO cells.
- CHO cells
- Mutagenicity testings
- Sister chromatid exchange assay
ASJC Scopus subject areas
- Health, Toxicology and Mutagenesis