Genotoxic effects of ketamine on CHO cells

S. G. Adhvaryu, A. H. Trivedi, K. H. Jani, R. C. Vyas, B. J. Dave

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Ketamine, a non-barbiturate anaesthetic agent, was studied for its genotoxic potential using the SCE assay. It was genotoxic in the in vitro system at concentrations comparable to the plasma levels achieved during steady state anaesthesia. It had no effects on cellular kinetics in CHO cells.

Original languageEnglish (US)
Pages (from-to)124-125
Number of pages2
JournalArchives of Toxicology
Volume59
Issue number2
DOIs
StatePublished - Jul 1986

Keywords

  • CHO cells
  • Ketamine
  • Mutagenicity testings
  • Sister chromatid exchange assay

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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