Genotoxic effects of nicotine in combination with arecoline on CHO cells

A. H. Trivedi; B. J. Dave; S. C. Adhvaryu

doi:10.1016/0304-3835(93)90051-A

Genotoxic effects of nicotine in combination with arecoline on CHO cells

A. H. Trivedi, B. J. Dave, S. C. Adhvaryu

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Genotoxic effects of nicotine and arecoline, major alkaloids of tobacco and areca nut, respectively, were analysed in combination on CHO cells utilising two different cytogenetic end points, namely chromosome aberration frequency and sister chromatid exchange frequency. Statistically significant elevation in the values of both markers compared with controls, as well as nicotine alone, clearly indicated a more clastogenic and genotoxic effect following the addition of areca nut to tobacco. The effects observed following the treatment with a low dose for a longer duration are of relevance to the condition of oral mucosa of the chewers of tobacco with areca nut.

Original language	English (US)
Pages (from-to)	105-110
Number of pages	6
Journal	Cancer Letters
Volume	74
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3835(93)90051-A
State	Published - Oct 15 1993
Externally published	Yes

Keywords

Arecoline
CHO cells
Genotoxicity
Nicotine

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/0304-3835(93)90051-A

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title = "Genotoxic effects of nicotine in combination with arecoline on CHO cells",

abstract = "Genotoxic effects of nicotine and arecoline, major alkaloids of tobacco and areca nut, respectively, were analysed in combination on CHO cells utilising two different cytogenetic end points, namely chromosome aberration frequency and sister chromatid exchange frequency. Statistically significant elevation in the values of both markers compared with controls, as well as nicotine alone, clearly indicated a more clastogenic and genotoxic effect following the addition of areca nut to tobacco. The effects observed following the treatment with a low dose for a longer duration are of relevance to the condition of oral mucosa of the chewers of tobacco with areca nut.",

keywords = "Arecoline, CHO cells, Genotoxicity, Nicotine",

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AU - Trivedi, A. H.

AU - Dave, B. J.

AU - Adhvaryu, S. C.

PY - 1993/10/15

Y1 - 1993/10/15

N2 - Genotoxic effects of nicotine and arecoline, major alkaloids of tobacco and areca nut, respectively, were analysed in combination on CHO cells utilising two different cytogenetic end points, namely chromosome aberration frequency and sister chromatid exchange frequency. Statistically significant elevation in the values of both markers compared with controls, as well as nicotine alone, clearly indicated a more clastogenic and genotoxic effect following the addition of areca nut to tobacco. The effects observed following the treatment with a low dose for a longer duration are of relevance to the condition of oral mucosa of the chewers of tobacco with areca nut.

AB - Genotoxic effects of nicotine and arecoline, major alkaloids of tobacco and areca nut, respectively, were analysed in combination on CHO cells utilising two different cytogenetic end points, namely chromosome aberration frequency and sister chromatid exchange frequency. Statistically significant elevation in the values of both markers compared with controls, as well as nicotine alone, clearly indicated a more clastogenic and genotoxic effect following the addition of areca nut to tobacco. The effects observed following the treatment with a low dose for a longer duration are of relevance to the condition of oral mucosa of the chewers of tobacco with areca nut.

KW - Arecoline

KW - CHO cells

KW - Genotoxicity

KW - Nicotine

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JO - Cancer Letters

JF - Cancer Letters

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ER -

Genotoxic effects of nicotine in combination with arecoline on CHO cells

Abstract

Keywords

ASJC Scopus subject areas

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