TY - JOUR
T1 - Geographic patterns of cancer in the population-based registry of Egypt
T2 - Possible links to environmental exposures
AU - Dey, Subhojit
AU - Zhang, Zhenzhen
AU - Hablas, Ahmed
AU - Seifeldein, Ibrahim A.
AU - Ramadan, Mohamed
AU - El-Hamzawy, Hesham
AU - Soliman, Amr S.
N1 - Funding Information:
GPCR was founded in 1998 as a part of the Middle East Cancer Consortium (MECC), which is funded by the National Cancer Institute (NCI), USA. The registry is located in Tanta, the capital of Gharbiah Province. This is an active cancer registry that collects cases from a number of sources in the province to determine cancer incidence. The registry has frequent site visits from IARC, NCI, and the steering committee of MECC for ensuring the high quality of the data and the results which are included in the Cancer Incidence of Five Continents [6] .
PY - 2011/6
Y1 - 2011/6
N2 - Background: We investigated the variation in cancer incidence in Gharbiah, Egypt to explore geographic differences in relation to demographic and environmental exposures. Methods: Using data from the only population-based cancer registry of Gharbiah, we studied the 10 most common cancers in men and women over 4 years (1999-2002). Census data provided denominators and urban-rural definitions. Crude and adjusted incidence rates (IRs), incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were estimated using Poisson regression. Results: Incidence of all common cancers was higher among men than women and urban incidence was higher than rural incidence for all cancer sites. Among men and women urban-rural incidence difference was highest for prostate cancer (IRR. = 4.85, 95% CI. = 3.76, 6.26) and uterus (IRR. = 6.05, 95% CI. = 4.17, 8.78), respectively. Among men and women, El-Santa district had the highest urban-rural difference within districts for laryngeal cancer (IRR. = 29.45, 95% CI. = 10.63, 81.61) and uterine cancer (IRR. = 15.98, 95% CI. = 2.69, 95.10), respectively. El-Santa also showed the highest urban incidence among all eight districts for most cancer sites. Conclusions: Geographic differences of cancers in Gharbiah need in-depth investigation with respect to specific environmental factors that explain the geographic cancer in this region.
AB - Background: We investigated the variation in cancer incidence in Gharbiah, Egypt to explore geographic differences in relation to demographic and environmental exposures. Methods: Using data from the only population-based cancer registry of Gharbiah, we studied the 10 most common cancers in men and women over 4 years (1999-2002). Census data provided denominators and urban-rural definitions. Crude and adjusted incidence rates (IRs), incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were estimated using Poisson regression. Results: Incidence of all common cancers was higher among men than women and urban incidence was higher than rural incidence for all cancer sites. Among men and women urban-rural incidence difference was highest for prostate cancer (IRR. = 4.85, 95% CI. = 3.76, 6.26) and uterus (IRR. = 6.05, 95% CI. = 4.17, 8.78), respectively. Among men and women, El-Santa district had the highest urban-rural difference within districts for laryngeal cancer (IRR. = 29.45, 95% CI. = 10.63, 81.61) and uterine cancer (IRR. = 15.98, 95% CI. = 2.69, 95.10), respectively. El-Santa also showed the highest urban incidence among all eight districts for most cancer sites. Conclusions: Geographic differences of cancers in Gharbiah need in-depth investigation with respect to specific environmental factors that explain the geographic cancer in this region.
KW - Cancer
KW - Cancer registries
KW - Developing countries
KW - Egypt
KW - Environmental exposures
KW - Geographic pattern
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U2 - 10.1016/j.canep.2010.09.010
DO - 10.1016/j.canep.2010.09.010
M3 - Article
C2 - 21036119
AN - SCOPUS:79955993887
SN - 1877-7821
VL - 35
SP - 254
EP - 264
JO - Cancer Epidemiology
JF - Cancer Epidemiology
IS - 3
ER -