Germline PAX5 mutations and B cell leukemia

R. Katherine Hyde; P. Paul Liu

doi:10.1038/ng.2778

Germline PAX5 mutations and B cell leukemia

R. Katherine Hyde, P. Paul Liu

Research output: Contribution to journal › Short survey › peer-review

14 Scopus citations

Abstract

The transcription factor PAX5 is required for normal B cell development and is frequently mutated or deleted in B cell precursor acute lymphoblastic leukemia (B-ALL). A new study demonstrates that germline hypomorphic mutations of PAX5 are associated with susceptibility to B-ALL, implicating PAX5 in a growing list of hematopoietic transcription factors mutated in familial leukemia predisposition syndromes.

Original language	English (US)
Pages (from-to)	1104-1105
Number of pages	2
Journal	Nature Genetics
Volume	45
Issue number	10
DOIs	https://doi.org/10.1038/ng.2778
State	Published - Oct 2013
Externally published	Yes

ASJC Scopus subject areas

Genetics

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10.1038/ng.2778

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title = "Germline PAX5 mutations and B cell leukemia",

abstract = "The transcription factor PAX5 is required for normal B cell development and is frequently mutated or deleted in B cell precursor acute lymphoblastic leukemia (B-ALL). A new study demonstrates that germline hypomorphic mutations of PAX5 are associated with susceptibility to B-ALL, implicating PAX5 in a growing list of hematopoietic transcription factors mutated in familial leukemia predisposition syndromes.",

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AU - Liu, P. Paul

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AB - The transcription factor PAX5 is required for normal B cell development and is frequently mutated or deleted in B cell precursor acute lymphoblastic leukemia (B-ALL). A new study demonstrates that germline hypomorphic mutations of PAX5 are associated with susceptibility to B-ALL, implicating PAX5 in a growing list of hematopoietic transcription factors mutated in familial leukemia predisposition syndromes.

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U2 - 10.1038/ng.2778

DO - 10.1038/ng.2778

M3 - Short survey

C2 - 24071841

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Germline PAX5 mutations and B cell leukemia

Abstract

ASJC Scopus subject areas

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