Germline PAX5 mutations and B cell leukemia

R. Katherine Hyde, P. Paul Liu

Research output: Contribution to journalShort surveypeer-review

7 Scopus citations


The transcription factor PAX5 is required for normal B cell development and is frequently mutated or deleted in B cell precursor acute lymphoblastic leukemia (B-ALL). A new study demonstrates that germline hypomorphic mutations of PAX5 are associated with susceptibility to B-ALL, implicating PAX5 in a growing list of hematopoietic transcription factors mutated in familial leukemia predisposition syndromes.

Original languageEnglish (US)
Pages (from-to)1104-1105
Number of pages2
JournalNature Genetics
Issue number10
StatePublished - Oct 2013
Externally publishedYes

ASJC Scopus subject areas

  • Genetics


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