Glandular stomach hemorrhage induced by high dose saccharin in young rodents

T. Okamura, E. M. Garland, S. M. Cohen

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

In studies primarily designed to evaluate the effects of saccharin and silicate on the urinary bladders of rodents, hemorrhage of the glandular stomach was observed in high incidence. It occurred in young rats with high doses of saccharin (7.5% sodium saccharin; 6.3% acid saccharin), with no difference between male and female F344 rats fed during ages 5 to 15 weeks, no difference between sodium saccharin and acid saccharin, and was reversible, even with continued saccharin administration. Sodium silicate (0.38, 1.13, 2.26% of the diet) had no influence on gastric hemorrhage. Iron deficiency anemia has been observed in young rats fed high dietary levels of saccharin, and the present results suggest that gastric hemorrhage contributes to its etiology.

Original languageEnglish (US)
Pages (from-to)129-140
Number of pages12
JournalToxicology Letters
Volume74
Issue number2
DOIs
StatePublished - Nov 1994

Keywords

  • Anemia
  • Hemorrhage
  • Iron deficiency
  • Saccharin
  • Stomach

ASJC Scopus subject areas

  • Toxicology

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