TY - JOUR
T1 - Global and selective detection of organohalogens in environmental samples by comprehensive two-dimensional gas chromatography-tandem mass spectrometry and high-resolution time-of-flight mass spectrometry
AU - Hashimoto, Shunji
AU - Takazawa, Yoshikatsu
AU - Fushimi, Akihiro
AU - Tanabe, Kiyoshi
AU - Shibata, Yasuyuki
AU - Ieda, Teruyo
AU - Ochiai, Nobuo
AU - Kanda, Hirooki
AU - Ohura, Takeshi
AU - Tao, Qingping
AU - Reichenbach, Stephen E.
PY - 2011/6/17
Y1 - 2011/6/17
N2 - We successfully detected halogenated compounds from several kinds of environmental samples by using a comprehensive two-dimensional gas chromatograph coupled with a tandem mass spectrometer (GC × GC-MS/MS). For the global detection of organohalogens, fly ash sample extracts were directly measured without any cleanup process. The global and selective detection of halogenated compounds was achieved by neutral loss scans of chlorine, bromine and/or fluorine using an MS/MS. It was also possible to search for and identify compounds using two-dimensional mass chromatograms and mass profiles obtained from measurements of the same sample with a GC × GC-high resolution time-of-flight mass spectrometer (HRTofMS) under the same conditions as those used for the GC × GC-MS/MS. In this study, novel software tools were also developed to help find target (halogenated) compounds in the data provided by a GC × GC-HRTofMS. As a result, many dioxin and polychlorinated biphenyl congeners and many other halogenated compounds were found in fly ash extract and sediment samples. By extracting the desired information, which concerned organohalogens in this study, from huge quantities of data with the GC × GC-HRTofMS, we reveal the possibility of realizing the total global detection of compounds with one GC measurement of a sample without any pre-treatment.
AB - We successfully detected halogenated compounds from several kinds of environmental samples by using a comprehensive two-dimensional gas chromatograph coupled with a tandem mass spectrometer (GC × GC-MS/MS). For the global detection of organohalogens, fly ash sample extracts were directly measured without any cleanup process. The global and selective detection of halogenated compounds was achieved by neutral loss scans of chlorine, bromine and/or fluorine using an MS/MS. It was also possible to search for and identify compounds using two-dimensional mass chromatograms and mass profiles obtained from measurements of the same sample with a GC × GC-high resolution time-of-flight mass spectrometer (HRTofMS) under the same conditions as those used for the GC × GC-MS/MS. In this study, novel software tools were also developed to help find target (halogenated) compounds in the data provided by a GC × GC-HRTofMS. As a result, many dioxin and polychlorinated biphenyl congeners and many other halogenated compounds were found in fly ash extract and sediment samples. By extracting the desired information, which concerned organohalogens in this study, from huge quantities of data with the GC × GC-HRTofMS, we reveal the possibility of realizing the total global detection of compounds with one GC measurement of a sample without any pre-treatment.
KW - Dioxins
KW - Halogenated PAHs
KW - Neutral loss scan
KW - PCBs
KW - POPs
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U2 - 10.1016/j.chroma.2011.04.042
DO - 10.1016/j.chroma.2011.04.042
M3 - Article
C2 - 21555130
AN - SCOPUS:79956265133
SN - 0021-9673
VL - 1218
SP - 3799
EP - 3810
JO - Journal of Chromatography A
JF - Journal of Chromatography A
IS - 24
ER -