Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis

Bart J. Crielaard; Cristianne J.F. Rijcken; Lingdong Quan; Steffen Van Der Wal; Isil Altintas; Martin Van Der Pot; John A.W. Kruijtzer; Rob M.J. Liskamp; Raymond M. Schiffelers; Cornelus F. Van Nostrum; Wim E. Hennink; Dong Wang; Twan Lammers; Gert Storm

doi:10.1002/anie.201202713

Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis

Bart J. Crielaard, Cristianne J.F. Rijcken, Lingdong Quan, Steffen Van Der Wal, Isil Altintas, Martin Van Der Pot, John A.W. Kruijtzer, Rob M.J. Liskamp, Raymond M. Schiffelers, Cornelus F. Van Nostrum, Wim E. Hennink, Dong Wang, Twan Lammers, Gert Storm

Research output: Contribution to journal › Article › peer-review

114 Scopus citations

Abstract

Polymerizable and hydrolytically cleavable dexamethasone (DEX, red dot in picture) derivatives were covalently entrapped in core-cross-linked polymeric micelles that were prepared from a thermosensitive block copolymer (yellow and gray building block). By varying the oxidation degree of the thioether in the drug linker, the release rate of DEX could be controlled. The DEX-loaded micelles were used for efficient treatment of inflammatory arthritis in two animal models.

Original language	English (US)
Pages (from-to)	7254-7258
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	29
DOIs	https://doi.org/10.1002/anie.201202713
State	Published - Jul 16 2012

Keywords

Drug delivery
Glucocorticoids
Micelles
Nanomedicine
Rheumatoid arthritis

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201202713

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Crielaard, B. J., Rijcken, C. J. F., Quan, L., Van Der Wal, S., Altintas, I., Van Der Pot, M., Kruijtzer, J. A. W., Liskamp, R. M. J., Schiffelers, R. M., Van Nostrum, C. F., Hennink, W. E., Wang, D., Lammers, T., & Storm, G. (2012). Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis. Angewandte Chemie - International Edition, 51(29), 7254-7258. https://doi.org/10.1002/anie.201202713

Crielaard, BJ, Rijcken, CJF, Quan, L, Van Der Wal, S, Altintas, I, Van Der Pot, M, Kruijtzer, JAW, Liskamp, RMJ, Schiffelers, RM, Van Nostrum, CF, Hennink, WE, Wang, D, Lammers, T & Storm, G 2012, 'Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis', Angewandte Chemie - International Edition, vol. 51, no. 29, pp. 7254-7258. https://doi.org/10.1002/anie.201202713

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abstract = "Polymerizable and hydrolytically cleavable dexamethasone (DEX, red dot in picture) derivatives were covalently entrapped in core-cross-linked polymeric micelles that were prepared from a thermosensitive block copolymer (yellow and gray building block). By varying the oxidation degree of the thioether in the drug linker, the release rate of DEX could be controlled. The DEX-loaded micelles were used for efficient treatment of inflammatory arthritis in two animal models.",

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AU - Quan, Lingdong

AU - Van Der Wal, Steffen

AU - Altintas, Isil

AU - Van Der Pot, Martin

AU - Kruijtzer, John A.W.

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AU - Schiffelers, Raymond M.

AU - Van Nostrum, Cornelus F.

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AU - Wang, Dong

AU - Lammers, Twan

AU - Storm, Gert

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Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis

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Keywords

ASJC Scopus subject areas

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