Gluconeogenesis in the newborn

Satish C. Kalhan, Zahi Zeidan

Research output: Contribution to journalArticlepeer-review


Gluconeogenesis, the formation of glucose from non-glucose carbon precursors, is expressed for the first time in most mammalian species immediately after birth. The appearance of gluconeogenesis, along with the contribution of glycogenolysis, is responsible for the maintenance of a steady rate of glucose production. The recent development of novel tracer isotopic methods have allowed precise quantification of the contribution of gluconeogenesis to glucose production in newborn infants and adults. These data show that gluconeogenesis is active both during fasting and during the fed state. In the healthy human newborn following a brief fast, gluconeogenesis via pyruvate contributes -30% to total glucose production.

Original languageEnglish (US)
Pages (from-to)245-255
Number of pages11
Issue number5
StatePublished - Sep 2002
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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