Abstract
Excitatory amino acid receptors in the neonatal rat hippocampus have opposing actions on phosphoinositide (PI) metabolism. Quisqualic acid (QA), but not the QA receptor agonist AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid), potently stimulates inositol phosphate (IP) formation. Activation of NMDA (N-methyl-d-aspartate) receptors inhibits the QA-induced stimulation by 70% by a mechanism which is dependent on extracellular calcium.
Original language | English (US) |
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Pages (from-to) | 161-165 |
Number of pages | 5 |
Journal | Molecular Brain Research |
Volume | 4 |
Issue number | 2 |
DOIs | |
State | Published - Sep 1988 |
Externally published | Yes |
Keywords
- 6-Cyano-2,3-dihydroxy-7-nitro-quinoxaline
- Calcium
- Glutamate receptor
- Hippocampus
- N-Methyl-d-aspartic acid
- Phosphoinositide metabolism
- Quisqualic acid
- α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid
ASJC Scopus subject areas
- Molecular Biology
- Cellular and Molecular Neuroscience