Glutamate receptors and phosphoinositide metabolism: stimulation via quisqualate receptors is inhibited by N-methyl-d-aspartate receptor activation

Elizabeth Palmer, Daniel T. Monaghan, Carl W. Cotman

Research output: Contribution to journalArticle

93 Scopus citations

Abstract

Excitatory amino acid receptors in the neonatal rat hippocampus have opposing actions on phosphoinositide (PI) metabolism. Quisqualic acid (QA), but not the QA receptor agonist AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid), potently stimulates inositol phosphate (IP) formation. Activation of NMDA (N-methyl-d-aspartate) receptors inhibits the QA-induced stimulation by 70% by a mechanism which is dependent on extracellular calcium.

Original languageEnglish (US)
Pages (from-to)161-165
Number of pages5
JournalMolecular Brain Research
Volume4
Issue number2
DOIs
StatePublished - Sep 1988

Keywords

  • 6-Cyano-2,3-dihydroxy-7-nitro-quinoxaline
  • Calcium
  • Glutamate receptor
  • Hippocampus
  • N-Methyl-d-aspartic acid
  • Phosphoinositide metabolism
  • Quisqualic acid
  • α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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