Glutamate receptors and phosphoinositide metabolism: stimulation via quisqualate receptors is inhibited by N-methyl-d-aspartate receptor activation

Elizabeth Palmer; Daniel T. Monaghan; Carl W. Cotman

doi:10.1016/0169-328X(88)90008-3

Glutamate receptors and phosphoinositide metabolism: stimulation via quisqualate receptors is inhibited by N-methyl-d-aspartate receptor activation

Elizabeth Palmer, Daniel T. Monaghan, Carl W. Cotman

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Abstract

Excitatory amino acid receptors in the neonatal rat hippocampus have opposing actions on phosphoinositide (PI) metabolism. Quisqualic acid (QA), but not the QA receptor agonist AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid), potently stimulates inositol phosphate (IP) formation. Activation of NMDA (N-methyl-d-aspartate) receptors inhibits the QA-induced stimulation by 70% by a mechanism which is dependent on extracellular calcium.

Original language	English (US)
Pages (from-to)	161-165
Number of pages	5
Journal	Molecular Brain Research
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/0169-328X(88)90008-3
State	Published - Sep 1988
Externally published	Yes

Keywords

6-Cyano-2,3-dihydroxy-7-nitro-quinoxaline
Calcium
Glutamate receptor
Hippocampus
N-Methyl-d-aspartic acid
Phosphoinositide metabolism
Quisqualic acid
α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

Access to Document

10.1016/0169-328X(88)90008-3

Cite this

@article{e5e2bde8b78941e5a8f53a1ef9ecd1c2,

title = "Glutamate receptors and phosphoinositide metabolism: stimulation via quisqualate receptors is inhibited by N-methyl-d-aspartate receptor activation",

abstract = "Excitatory amino acid receptors in the neonatal rat hippocampus have opposing actions on phosphoinositide (PI) metabolism. Quisqualic acid (QA), but not the QA receptor agonist AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid), potently stimulates inositol phosphate (IP) formation. Activation of NMDA (N-methyl-d-aspartate) receptors inhibits the QA-induced stimulation by 70% by a mechanism which is dependent on extracellular calcium.",

keywords = "6-Cyano-2,3-dihydroxy-7-nitro-quinoxaline, Calcium, Glutamate receptor, Hippocampus, N-Methyl-d-aspartic acid, Phosphoinositide metabolism, Quisqualic acid, α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid",

author = "Elizabeth Palmer and Monaghan, {Daniel T.} and Cotman, {Carl W.}",

year = "1988",

month = sep,

doi = "10.1016/0169-328X(88)90008-3",

language = "English (US)",

volume = "4",

pages = "161--165",

journal = "Molecular Brain Research",

issn = "0169-328X",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - Glutamate receptors and phosphoinositide metabolism

T2 - stimulation via quisqualate receptors is inhibited by N-methyl-d-aspartate receptor activation

AU - Palmer, Elizabeth

AU - Monaghan, Daniel T.

AU - Cotman, Carl W.

PY - 1988/9

Y1 - 1988/9

N2 - Excitatory amino acid receptors in the neonatal rat hippocampus have opposing actions on phosphoinositide (PI) metabolism. Quisqualic acid (QA), but not the QA receptor agonist AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid), potently stimulates inositol phosphate (IP) formation. Activation of NMDA (N-methyl-d-aspartate) receptors inhibits the QA-induced stimulation by 70% by a mechanism which is dependent on extracellular calcium.

AB - Excitatory amino acid receptors in the neonatal rat hippocampus have opposing actions on phosphoinositide (PI) metabolism. Quisqualic acid (QA), but not the QA receptor agonist AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid), potently stimulates inositol phosphate (IP) formation. Activation of NMDA (N-methyl-d-aspartate) receptors inhibits the QA-induced stimulation by 70% by a mechanism which is dependent on extracellular calcium.

KW - 6-Cyano-2,3-dihydroxy-7-nitro-quinoxaline

KW - Calcium

KW - Glutamate receptor

KW - Hippocampus

KW - N-Methyl-d-aspartic acid

KW - Phosphoinositide metabolism

KW - Quisqualic acid

KW - α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid

UR - http://www.scopus.com/inward/record.url?scp=0024086158&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024086158&partnerID=8YFLogxK

U2 - 10.1016/0169-328X(88)90008-3

DO - 10.1016/0169-328X(88)90008-3

M3 - Article

C2 - 2905924

AN - SCOPUS:0024086158

SN - 0169-328X

VL - 4

SP - 161

EP - 165

JO - Molecular Brain Research

JF - Molecular Brain Research

IS - 2

ER -

Glutamate receptors and phosphoinositide metabolism: stimulation via quisqualate receptors is inhibited by N-methyl-d-aspartate receptor activation

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this