Glutathione s-transferases in cancer

Rahul Raj Singh, Katie M. Reindl

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

In humans, the glutathione S-transferases (GST) protein family is composed of seven members that present remarkable structural similarity and some degree of overlapping functionalities. GST proteins are crucial antioxidant enzymes that regulate stress-induced signaling pathways. Interestingly, overactive GST proteins are a frequent feature of many human cancers. Recent evidence has revealed that the biology of most GST proteins is complex and multifaceted and that these proteins actively participate in tumorigenic processes such as cell survival, cell proliferation, and drug resistance. Structural and pharmacological studies have identified various GST inhibitors, and these molecules have progressed to clinical trials for the treatment of cancer and other diseases. In this review, we discuss recent findings in GST protein biology and their roles in cancer development, their contribution in chemoresistance, and the development of GST inhibitors for cancer treatment.

Original languageEnglish (US)
Article number701
JournalAntioxidants
Volume10
Issue number5
DOIs
StatePublished - 2021

Keywords

  • Antioxidants
  • Apoptosis
  • Cancer-cell signaling
  • Chemoresistance
  • GST inhibitors
  • Glutathione S-transferases (GSTs)
  • Glutathionylation
  • JNK
  • Metabolism
  • Oxidative stress
  • Patient survival
  • Xenobiotic compounds

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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