@article{9486d1c19bf544ca8e32e3dd80ec876c,
title = "Glycemic Variability in Patients With Stage II–III Colon Cancer Treated With Surgery and Adjuvant Chemotherapy",
abstract = "OBJECTIVES: To examine glycemic variability within one month and one year following surgery and throughout adjuvant chemotherapy among patients with stage II–III colon cancer, with and without type 2 diabetes (T2D). SAMPLE & SETTING: 58 patients with stage II–III colon cancer treated with surgery and chemotherapy. METHODS & VARIABLES: A retrospective analysis of electronic health record data over one year showed glycemic variability, measured as standard deviation and coefficient of variation. Chi-square, Fisher{\textquoteright}s exact, and Mann–Whitney U tests and Spearman{\textquoteright}s correlation coefficient were calculated. RESULTS: Patients with T2D had higher glycemic variability throughout chemotherapy and within one year following surgery. A significant increase in glycemic variability throughout chemotherapy was observed in patients without T2D. Significant associations between glycemic variability and demographic and clinical characteristics differed by T2D status, standard deviation, and coefficient of variation. IMPLICATIONS FOR NURSING: Nurses need to assess serial blood glucose levels in patients with and without T2D. Teaching patients how to maintain glycemic control during treatment is a priority. Research should include predictive models to identify risk factors for higher glycemic variability and cancer-related symptoms and outcomes.",
keywords = "chemotherapy, colon cancer, glucose, glycemic variability, steroids, surgery",
author = "Mandolfo, {Natalie Rasmussen} and Berger, {Ann M.} and Struwe, {Leeza A.} and Shade, {Marcia Y.} and Whitney Goldner and Kelsey Klute and Langenfeld, {Sean J.} and Hammer, {Marilyn J.}",
note = "Funding Information: at the time of this writing, a PhD student; Ann M. Berger, PhD, MSN, FAAN, is a professor and an advanced practice nurse, Leeza A. Struwe, PhD, MSN, RN, is an associate professor, and Marcia Y. Shade, BS, PhD, RN, is an assistant professor, all in the College of Nursing; Whitney Goldner, MD, is a physician and professor of medicine in the Division of Diabetes, Endocrinology, and Metabolism in the Department of Internal Medicine; Kelsey Klute, MD, is a medical oncologist and an assistant professor in the Division of Oncology and Hematology in the Department of Internal Medicine; and Sean J. Langenfeld, MD, FACS, FASCRS, is a professor of surgery in the Department of Surgery, all at the University of Nebraska Medical Center in Omaha; and Marilyn J. Hammer, PhD, DC, RN, FAAN, is the director of the Phyllis F. Cantor Center for Research in Nursing and Patient Care Services at the Dana-Farber Cancer Institute in Boston, MA. Mandolfo can be reached at nmandolfo5@cox.net, with copy to ONFEditor@ons.org. (Submitted November 2021. Accepted March 21, 2022.) The research and publication were supported, in part, by the Fred and Pamela Buffett Cancer Center Support Grant from the National Cancer Institute under award number P30 CA036727 and the following scholarships: Oncology Nursing Society Foundation Research Doctoral Scholarship, Sigma Theta Tau International Gamma-Pi At Large Chapter, University of Nebraska Foundation Ann Malone Berger Ph.D. and Thomas Berger Nursing Fund, and University of Nebraska Foundation Versal H. and Edith Molly Stevens Caton Scholarship. Publisher Copyright: {\textcopyright} 2022, Oncology Nursing Society. All rights reserved.",
year = "2022",
month = nov,
doi = "10.1188/22.ONF.571-584",
language = "English (US)",
volume = "49",
pages = "571--584",
journal = "Oncology nursing forum",
issn = "0190-535X",
publisher = "Oncology Nursing Society",
number = "6",
}