Glycocalyx–Sodium Interaction in Vascular Endothelium

Lawrence Fred Sembajwe, Abdul M. Ssekandi, Agnes Namaganda, Haruna Muwonge, Josephine N. Kasolo, Robert Kalyesubula, Annettee Nakimuli, Mwesigwa Naome, Kaushik P. Patel, Sepiso K. Masenga, Annet Kirabo

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

The glycocalyx generally covers almost all cellular surfaces, where it participates in mediating cell-surface interactions with the extracellular matrix as well as with intracellular signaling molecules. The endothelial glycocalyx that covers the luminal surface mediates the interactions of endothelial cells with materials flowing in the circulating blood, including blood cells. Cardiovascular diseases (CVD) remain a major cause of morbidity and mortality around the world. The cardiovascular risk factors start by causing endothelial cell dysfunction associated with destruction or irregular maintenance of the glycocalyx, which may culminate into a full-blown cardiovascular disease. The endothelial glycocalyx plays a crucial role in shielding the cell from excessive exposure and absorption of excessive salt, which can potentially cause damage to the endothelial cells and underlying tissues of the blood vessels. So, in this mini review/commentary, we delineate and provide a concise summary of the various components of the glycocalyx, their interaction with salt, and subsequent involvement in the cardiovascular disease process. We also highlight the major components of the glycocalyx that could be used as disease biomarkers or as drug targets in the management of cardiovascular diseases.

Original languageEnglish (US)
Article number2873
JournalNutrients
Volume15
Issue number13
DOIs
StatePublished - Jul 2023

Keywords

  • CVD
  • endothelial-glycocalyx
  • glypicans
  • hyaluronan
  • hypertension
  • proteoglycans
  • sodium chloride-salt
  • syndecans

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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