Abstract
Background: The Golgi docking mechanisms for transport vesicles carrying glycosyltransferases are largely unknown. Results: C1GalT1 utilizes GM130-GRASP65 when GRASP65 is available but GM130-Giantin without GRASP65, whereas C2GnT-M employs Giantin for Golgi targeting. Conclusion: The Golgi-targeting mechanism is glycosyltransferase-specific. Significance: Understanding the Golgi-targeting mechanisms of glycosyltransferases may help uncover altered glycosylation in some diseases.
Original language | English (US) |
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Pages (from-to) | 37621-37627 |
Number of pages | 7 |
Journal | Journal of Biological Chemistry |
Volume | 287 |
Issue number | 45 |
DOIs | |
State | Published - Nov 2 2012 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology