GM-CSF induces neuroprotective and anti-inflammatory responses in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxicated mice

Lisa M. Kosloski, Elizabeth A. Kosmacek, Katherine E. Olson, R. Lee Mosley, Howard E. Gendelman

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Innate and adaptive immune responses can speed nigrostriatal neurodegeneration in Parkinson's disease (PD). We posit that GM-CSF can attenuate such responses. In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxicated mice, GM-CSF given prior to MPTP protected nigral dopaminergic neurons coincident with altered microglial morphologies and regulatory T cell (Treg) induction. Adoptive transfer of GM-CSF-induced Treg to MPTP mice protected nigral neurons. Gene expression analyses revealed novel immune-based neuronal protection pathways linked to the upregulation of IL-27. The results provide evidence that GM-CSF modulation of immunity could be of clinical benefit for PD.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalJournal of Neuroimmunology
Volume265
Issue number1-2
DOIs
StatePublished - Dec 15 2013

Keywords

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Innate immunity
  • Neuroinflammation
  • Neuroprotection
  • Parkinson's disease
  • Regulatory T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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