Gonococcal Infection: A Model of Molecular Pathogenesis

Bradley E. Britigan, Myron S. Cohen, P. Frederick Sparling

Research output: Contribution to journalReview articlepeer-review

95 Scopus citations


Human beings are the only reservoir for the gonococcus. In spite of public health efforts to control this pathogen, and the availability of adequate antibiotic therapy for 40 years, close to a million cases of gonococcal infection are reported in the United States annually.1 The increasing prevalence of antibiotic-resistant strains has complicated treatment regimens.2 3 4 5 Sequelae of gonococcal infection, including sterility and ectopic pregnancy, are serious health problems,6 particularly in less developed areas of the world. The gonococcus infects a diverse array of mucosal surfaces, including the urethra, endocervix, pharynx, conjunctiva, and rectum. In a minority of patients these infections progress.

Original languageEnglish (US)
Pages (from-to)1683-1694
Number of pages12
JournalNew England Journal of Medicine
Issue number26
StatePublished - Jun 27 1985
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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