TY - JOUR
T1 - Gonococcal Infection
T2 - A Model of Molecular Pathogenesis
AU - Britigan, Bradley E.
AU - Cohen, Myron S.
AU - Sparling, P. Frederick
PY - 1985/6/27
Y1 - 1985/6/27
N2 - Human beings are the only reservoir for the gonococcus. In spite of public health efforts to control this pathogen, and the availability of adequate antibiotic therapy for 40 years, close to a million cases of gonococcal infection are reported in the United States annually.1 The increasing prevalence of antibiotic-resistant strains has complicated treatment regimens.2 3 4 5 Sequelae of gonococcal infection, including sterility and ectopic pregnancy, are serious health problems,6 particularly in less developed areas of the world. The gonococcus infects a diverse array of mucosal surfaces, including the urethra, endocervix, pharynx, conjunctiva, and rectum. In a minority of patients these infections progress.
AB - Human beings are the only reservoir for the gonococcus. In spite of public health efforts to control this pathogen, and the availability of adequate antibiotic therapy for 40 years, close to a million cases of gonococcal infection are reported in the United States annually.1 The increasing prevalence of antibiotic-resistant strains has complicated treatment regimens.2 3 4 5 Sequelae of gonococcal infection, including sterility and ectopic pregnancy, are serious health problems,6 particularly in less developed areas of the world. The gonococcus infects a diverse array of mucosal surfaces, including the urethra, endocervix, pharynx, conjunctiva, and rectum. In a minority of patients these infections progress.
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U2 - 10.1056/NEJM198506273122606
DO - 10.1056/NEJM198506273122606
M3 - Review article
C2 - 2860565
AN - SCOPUS:0022253699
SN - 0028-4793
VL - 312
SP - 1683
EP - 1694
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 26
ER -