Granular cell leiomyoma of the oral cavity

Indraneel Bhattacharyya, Don John Summerlin, Donald M. Cohen, Gary L. Ellis, Joseph B. Bavitz, Lamont L. Gillham

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Granular cytoplasmic change is a reported but uncommon finding in leiomyoma. Leiomyoma in the oral cavity is also uncommon, and granular cell change in oral leiomyomas, to the best of our knowledge, has not been previously reported in the English literature. Two cases of oral leiomyomas with significant granular cell change are presented. These tumors may be confused with the more common granular cell tumor, however, routine histology and immunohistochemistry aided in establishing the diagnosis. Ultrastructural studies were done for one case. Both tumors were immunoreactive for muscle markers, namely, smooth muscle actin and desmin. One of the tumors (case 2) reacted postiviely for HHF-35 and alpha-1 antitrypsin. The tumors were unreactive for S-100 protein, pancytokeratin, myoglobin, and factor VIII related antigen (case 2).

Original languageEnglish (US)
Pages (from-to)353-359
Number of pages7
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
Issue number3
StatePublished - Sep 2006

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology
  • General Dentistry


Dive into the research topics of 'Granular cell leiomyoma of the oral cavity'. Together they form a unique fingerprint.

Cite this