Granulocyte-macrophage colony-stimulating factor (GM-CSF): Answers or more questions?

J. M. Vose, P. J. Bierman, J. O. Armitage

Research output: Contribution to journalEditorialpeer-review

6 Scopus citations


The use of colony-stimulating factors has now become standard practice for most patients undergoing high-dose chemotherapy and autologous bone marrow or peripheral stem cell transplantation. However, the following questions, among others, remain unanswered: Which growth factor or combination of growth factors will allow for the fastest engraftment after transplantation? What is the best mode of administration and dosage for the various factors? And, most important, will the use of colony-stimulating factors allow us to cure more patients of their malignancy? These questions must be answered in controlled clinical trials so that we might best use the resources available for the patient's ultimate benefit.

Original languageEnglish (US)
Pages (from-to)261-262
Number of pages2
JournalAnnals of internal medicine
Issue number3
StatePublished - 1992


  • Bone marrow transplantation
  • Granulocyte-macrophage colony-stimulating factor
  • Neutropenia
  • Stem cells
  • Transplantation, autologous

ASJC Scopus subject areas

  • Internal Medicine


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