Abstract
We investigated the effects of granulocyte-macrophage colony stimulating factor (GM-CSF) on behavioral and pathological outcomes in Alzheimer's disease (AD) and non-transgenic mice. GM-CSF treatment in AD mice reduced brain amyloidosis, increased plasma Aβ and rescued cognitive impairment with increased hippocampal expression of calbindin and synaptophysin and increased levels of doublecortin-positive cells in the dentate gyrus. These data extend GM-CSF pleiotropic neuroprotection mechanisms in AD and include regulatory T cell-mediated immunomodulation of microglial function, Aβ clearance, maintenance of synaptic integrity, and induction of neurogenesis. Together these data support further development of GM-CSF as a neuroprotective agent for AD.
Original language | English (US) |
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Pages (from-to) | 80-92 |
Number of pages | 13 |
Journal | Journal of Neuroimmunology |
Volume | 319 |
DOIs | |
State | Published - Jun 15 2018 |
Keywords
- APP/PS1 mice
- Amyloidosis
- Aβ plaques
- Calbindin
- Cognitive function
- Doublecortin
- Hippocampus
- Synaptophysin
- Tregs
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology