@inproceedings{d055821cb1694e3b9f816225744733dc,
title = "Graph-based analysis of genetic features associated with mobile elements in Crohn{\textquoteright}s disease and healthy gut microbiomes",
abstract = "Horizontal gene transfer is a major driver of bacterial evolution and adaptation to niche environments. This holds true for the complex microbiome of the human gut. Crohn{\textquoteright}s disease is a debilitating condition characterized by inflammation and gut bacteria dysbiosis. In previous research, we analyzed transposase associated antibiotic resistance genes in Crohn{\textquoteright}s disease and healthy gut microbiome metagenomics data sets using a graph mining approach. Results demonstrated that there were significant differences in the type and bacterial distribution of transposase-associated antibiotic resistance genes in the Crohn{\textquoteright}s and healthy data sets. In this paper, we extend the previous research by considering all gene features associated with transposase sequences in the Crohn{\textquoteright}s disease and healthy data sets. Results demonstrate that some transposase-associated features are more prevalent in Crohn{\textquoteright}s disease data sets than healthy data sets. This study may provide insights into the adaptation of bacteria to gut conditions such as Crohn{\textquoteright}s disease.",
keywords = "Crohn{\textquoteright}s Disease, Graph Theory, Metagenomics, Mobile Elements, Next Generation Sequencing",
author = "Julia Warnke-Sommer and Hesham Ali",
note = "Publisher Copyright: Copyright {\textcopyright} 2017 by SCITEPRESS – Science and Technology Publications, Lda. All rights reserved.; 8th International Conference on Bioinformatics Models, Methods and Algorithms, BIOINFORMATICS 2017 - Part of 10th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2017 ; Conference date: 21-02-2017 Through 23-02-2017",
year = "2017",
doi = "10.5220/0006254201040114",
language = "English (US)",
series = "BIOINFORMATICS 2017 - 8th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 10th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2017",
publisher = "SciTePress",
pages = "104--114",
editor = "Hesham Ali and Ana Fred and Hugo Gamboa and Mario Vaz",
booktitle = "BIOINFORMATICS 2017 - 8th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 10th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2017",
}