Grid-layout visualization method in the microarray data analysis interactive graphics toolkit

Li Xiao, O. Shats, S. Sherman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

The expression levels of thousands of genes in different tissues or cells in different conditions can be detected all at one time by DNA microarray technology. A new, grid-layout method for the visualization results of hierarchical cluster analysis of DNA microarray data is proposed and incorporated in the microarray interactive graphics toolkit (MIGT). The grid-layout consists of a set of regular, two-dimensional grid units. Each unit represents a cluster or a group of gene clusters. The units are connected to adjacent ones by the neighborhood relation of the clusters in a hierarchical tree. Nodes lying near each other in the hierarchical tree are mapped onto nearby grid-layout units. The number of units may vary on a scale from a few dozen up to several thousands, depending on the number of the nodes in a hierarchical tree. Different colors are assigned to the units with RGB value according to the coordinates of the units, and the inter-distances, which are the distances between clusters in a hierarchical tree, and the intra-distances, which are the distances between genes within one cluster. The closer the inter-distances, the more similar the color of the units are, the smaller the intra-distances, the warmer the color of the unit is.

Original languageEnglish (US)
Title of host publicationProceedings of the 36th Annual Hawaii International Conference on System Sciences, HICSS 2003
EditorsRalph H. Sprague
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)0769518745, 9780769518749
DOIs
StatePublished - 2003
Event36th Annual Hawaii International Conference on System Sciences, HICSS 2003 - Big Island, United States
Duration: Jan 6 2003Jan 9 2003

Publication series

NameProceedings of the 36th Annual Hawaii International Conference on System Sciences, HICSS 2003

Other

Other36th Annual Hawaii International Conference on System Sciences, HICSS 2003
CountryUnited States
CityBig Island
Period1/6/031/9/03

ASJC Scopus subject areas

  • Information Systems
  • Computer Science Applications

Fingerprint Dive into the research topics of 'Grid-layout visualization method in the microarray data analysis interactive graphics toolkit'. Together they form a unique fingerprint.

  • Cite this

    Xiao, L., Shats, O., & Sherman, S. (2003). Grid-layout visualization method in the microarray data analysis interactive graphics toolkit. In R. H. Sprague (Ed.), Proceedings of the 36th Annual Hawaii International Conference on System Sciences, HICSS 2003 [1174805] (Proceedings of the 36th Annual Hawaii International Conference on System Sciences, HICSS 2003). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/HICSS.2003.1174805