GROalpha

Dongsheng Xu; Shelley Herek; Jialin Zheng

doi:10.1016/B978-008055232-3.61850-1

GROalpha

Dongsheng Xu, Shelley Herek, Jialin Zheng

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Growth-related oncogene-alpha (GROalpha) belongs to a family of chemokines that consist of small proinflammatory cytokines (approximately 8-14 kD) and structurally related molecules that regulate cell trafficking of various types of leukocytes. Chemokines are involved in migration of inflammatory cells and play fundamental roles in the development, homeostasis, and function of the immune system. They also have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. GROalpha and its receptor CXCR2 are involved in chemoattraction, neovascularization, proliferation, and migration of inflammatory cells. GROalpha is also involved in the proliferation and migration of oligodendrocyte progenitors and in the stimulation of HIV-1 replication. Kershaw and colleagues. © 2007

Original language	English (US)
Title of host publication	xPharm
Subtitle of host publication	The Comprehensive Pharmacology Reference
Publisher	Elsevier Inc.
Pages	1-3
Number of pages	3
ISBN (Print)	9780080552323
DOIs	https://doi.org/10.1016/B978-008055232-3.61850-1
State	Published - 2007

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics

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10.1016/B978-008055232-3.61850-1

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title = "GROalpha",

abstract = "Growth-related oncogene-alpha (GROalpha) belongs to a family of chemokines that consist of small proinflammatory cytokines (approximately 8-14 kD) and structurally related molecules that regulate cell trafficking of various types of leukocytes. Chemokines are involved in migration of inflammatory cells and play fundamental roles in the development, homeostasis, and function of the immune system. They also have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. GROalpha and its receptor CXCR2 are involved in chemoattraction, neovascularization, proliferation, and migration of inflammatory cells. GROalpha is also involved in the proliferation and migration of oligodendrocyte progenitors and in the stimulation of HIV-1 replication. Kershaw and colleagues. {\textcopyright} 2007",

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AU - Xu, Dongsheng

AU - Herek, Shelley

AU - Zheng, Jialin

PY - 2007

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N2 - Growth-related oncogene-alpha (GROalpha) belongs to a family of chemokines that consist of small proinflammatory cytokines (approximately 8-14 kD) and structurally related molecules that regulate cell trafficking of various types of leukocytes. Chemokines are involved in migration of inflammatory cells and play fundamental roles in the development, homeostasis, and function of the immune system. They also have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. GROalpha and its receptor CXCR2 are involved in chemoattraction, neovascularization, proliferation, and migration of inflammatory cells. GROalpha is also involved in the proliferation and migration of oligodendrocyte progenitors and in the stimulation of HIV-1 replication. Kershaw and colleagues. © 2007

AB - Growth-related oncogene-alpha (GROalpha) belongs to a family of chemokines that consist of small proinflammatory cytokines (approximately 8-14 kD) and structurally related molecules that regulate cell trafficking of various types of leukocytes. Chemokines are involved in migration of inflammatory cells and play fundamental roles in the development, homeostasis, and function of the immune system. They also have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. GROalpha and its receptor CXCR2 are involved in chemoattraction, neovascularization, proliferation, and migration of inflammatory cells. GROalpha is also involved in the proliferation and migration of oligodendrocyte progenitors and in the stimulation of HIV-1 replication. Kershaw and colleagues. © 2007

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DO - 10.1016/B978-008055232-3.61850-1

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SN - 9780080552323

SP - 1

EP - 3

BT - xPharm

PB - Elsevier Inc.

ER -

GROalpha

Abstract

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