TY - JOUR
T1 - Growth factors in the regenerating pancreas of γ-interferon transgenic mice
AU - Arnush, Marc
AU - Gu, Danling
AU - Baugh, Chris
AU - Sawyer, Stephen P.
AU - Mroczkowski, Barbara
AU - Krahl, Troy
AU - Sarvetnick, Nora
PY - 1996/6
Y1 - 1996/6
N2 - We examined the distribution of several relevant growth factors in γ- interferon transgenic mice, which undergo continual growth and differentiation in the pancreas. As a result, epidermal growth factor (EGF), TGF-α, and the EGF receptor were identified as potentially important in mediating some of these regenerative changes. Transient up-regulation of EGF, TGF-α, and the EGF receptor were observed in acinii undergoing differentiation into duct-like structures. These ducts have been shown to proliferate and potentiate regeneration of the pancreatic islet mass.
AB - We examined the distribution of several relevant growth factors in γ- interferon transgenic mice, which undergo continual growth and differentiation in the pancreas. As a result, epidermal growth factor (EGF), TGF-α, and the EGF receptor were identified as potentially important in mediating some of these regenerative changes. Transient up-regulation of EGF, TGF-α, and the EGF receptor were observed in acinii undergoing differentiation into duct-like structures. These ducts have been shown to proliferate and potentiate regeneration of the pancreatic islet mass.
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M3 - Article
C2 - 8667616
AN - SCOPUS:0030013463
SN - 0023-6837
VL - 74
SP - 985
EP - 990
JO - Laboratory Investigation
JF - Laboratory Investigation
IS - 6
ER -